Aims/hypothesis Low birthweight (LBW) is associated with dysfunctions of adipose tissue
and metabolic disease in adult life. We hypothesised that altered epigenetic and …

Background TCF7L2 is a central transcription factor in the canonical wingless-type MMTV
integration site (WNT) signaling pathway, and genetic variants in TCF7L2 have been found …

Background Oxidative stress has been related to type 2 diabetes (T2D) and cardiovascular
disease (CVD), the leading global cause of death. Contributions of environmental factors …

Aims/hypothesis Genome-wide association studies (GWAS) have discovered many risk
variants for type 2 diabetes. However, estimates of the contributions of risk variants to type 2 …

Genome‐wide association studies (GWASs) for complex diseases often collect data on
multiple correlated endo‐phenotypes. Multivariate analysis of these correlated phenotypes …

The mammalian circadian clock plays a central role in the temporal coordination of
physiology across the 24-h light-dark cycle. A major function of the clock is to maintain …

Obesity has become epidemic worldwide, and abdominal obesity has a negative impact on
health. Current treatment options on obesity, however, still remain limited. It is then of …

Abstract Background Long-chain (> 20 C-atoms) polyunsaturated fatty acids (LC PUFAs) of
both the omega-6 (n-6) and omega-3 (n-3) series are important for the functional integrity of …

Large genome-wide association studies of glycemic traits have identified genetics variants
that are associated with insulin resistance (IR) in the general population. It is unknown …

The transcription factor Glis-similar 3 (Glis3) has been implicated in the development of
neonatal, type 1 and type 2 diabetes. In this study, we examined the spatiotemporal …