Background: In observational studies, high levels of gamma-glutamyltransferase (GGT) have
been associated with a higher risk of type 2 diabetes mellitus (T2D). We aimed to assess …

The sleep electroencephalogram (EEG) is highly heritable in humans and yet little is known
about the genetic basis of inter-individual differences in sleep architecture. The aim of this …

Adequate plasma, cellular, and tissue vitamin C concentrations are required for maintaining
optimal health through suppression of oxidative stress and optimizing functions of certain …

Loci discovered by genome-wide association studies (GWAS) predominantly map outside
protein-coding genes. The interpretation of functional consequences of non-coding variants …

Long intergenic noncoding RNAs (lincRNAs) play important roles in disease, but the vast
majority of these transcripts remain uncharacterized. We defined a set of 54 944 human …

In this study, we identify a novel and essential role for the Krüppel-like zinc finger
transcription factor GLI-similar 3 (GLIS3) in the regulation of postnatal spermatogenesis. We …

Circadian rhythms govern vital functions. Their disruption provokes metabolic imbalance
favouring obesity and type-2 diabetes. The aim of the study was to assess the role of clock …

Background The prevalence of type 2 diabetes (T2D) is increasing in the Middle East.
However, the genetic risk factors for T2D in the Middle Eastern populations are not known …

In mammals, because they share a single synthetic pathway, n-6/n-3 ratios of dietary PUFAs
impact tissue arachidonic acid (ARA) and DHA content. Likewise, SNPs in the human fatty …

Objective: Weight-loss intervention through diet modification has been widely used to
improve obesity-related hyperglycemia; however, little is known about whether genetic …