Background Multiple genetic loci are associated with clinical cardiovascular (CV) disease
and individual CV risk factors. Individuals with ideal levels of all major CV risk factors have …

OBJECTIVE We examined whether the addition of novel genetic risk variant data to
conventional childhood risk factors improves risk assessment of impaired fasting glucose …

Glucose-stimulated insulin secretion (GSIS) by pancreatic β cells is biphasic. However, the
physiological significance of biphasic GSIS and its relationship to diabetes are not yet fully …

Diabetogenic single nucleotide polymorphisms (SNPs) have recently been associated with
multiple myeloma (MM) risk but their impact on overall survival (OS) of MM patients has not …

Transcription factor expression fluctuates during β-cell ontogeny, and disruptions in this
pattern can affect the development or function of those cells. Here we uncovered that murine …

Background—The chemokine receptors CCR2, CCR5, and CX3CR1 coordinate monocyte
trafficking in homeostatic and inflammatory states. Multiple small human genetic studies …

Aims It has recently been shown that an allele in the glucokinase regulatory protein (GCKR)
gene was associated with increased liver fat content in obese children. In this study, we set …

The rapidly increasing prevalence of type 2 diabetes (T2D) is motivating an intensive search
for biomarkers to identify individuals at risk for developing the disease. It has been …

Abstract Type 2 diabetes (T2D) is a chronic metabolic disease which shows an exponential
increase in all parts of the world. However, the disease is controllable by early detection and …

Aim To investigate the genetic influence of circulating lactate level, a marker of oxidative
capacity associated with diabetes. Methods We conducted a genome‐wide association …