As with other complex diseases, unbiased association studies followed by physiological and
experimental characterization have for years formed a paradigm for identifying genes or …

To date, more than 30 genes have been linked to monogenic diabetes. Candidate gene and
genome-wide association studies have identified> 50 susceptibility loci for common type 1 …

The field of the genetics of polycystic ovary syndrome (PCOS) has relatively recently moved
into the era of genome-wide association studies. This has led to the discovery of 16 robust …

Motivation: A dominant approach to genetic association studies is to perform univariate tests
between genotype-phenotype pairs. However, analyzing related traits together increases …

Genetic and epigenetic factors may predispose women to polycystic ovary syndrome
(PCOS), a common heritable disorder of unclear etiology. Here we investigated differences …

Abstract Background The German Diabetes Study (GDS) is a prospective longitudinal cohort
study describing the impact of subphenotypes on the course of the disease. GDS aims at …

Although the gut microbiome plays important roles in host physiology, health and disease 1,
we lack understanding of the complex interplay between host genetics and early life …

Although relatively rare, pancreatic tumors are highly lethal [1]. In the United States, an
estimated 48,960 individuals will be diagnosed with pancreatic cancer and 40,560 will die …

Cerebral small vessel disease (SVD) is among the most frequent causes of both stroke and
dementia. There is a growing list of genes known to be implicated in Mendelian forms of …

Studies that traverse ancestrally diverse populations may increase power to detect novel loci
and improve fine-mapping resolution of causal variants by leveraging linkage disequilibrium …