Acute infectious gastroenteritis potentiates a Crohn's disease pathobiont to fuel ongoing inflammation in the post-infectious period

CL Small, L Xing, JB McPhee, HT Law… - PLoS …, 2016 - journals.plos.org
Crohn's disease (CD) is a chronic inflammatory condition of diverse etiology. Exposure to
foodborne pathogens causing acute gastroenteritis produces a long-term risk of CD well into …

Persistent infection with Crohn's disease-associated adherent-invasive Escherichia coli leads to chronic inflammation and intestinal fibrosis

CLN Small, SA Reid-Yu, JB McPhee… - Nature …, 2013 - nature.com
Crohn's disease is a chronic inflammatory condition of the gastrointestinal tract in which
alterations to the bacterial community contribute to disease. Adherent-invasive Escherichia …

[HTML][HTML] Subversion of human intestinal mucosa innate immunity by a Crohn's disease-associated E. coli

A Jarry, L Crémet, N Caroff, C Bou-Hanna… - Mucosal …, 2015 - Elsevier
Adherent-invasive Escherichia coli (AIEC), associated with Crohn's disease, are likely
candidate contributory factors in the disease. However, signaling pathways involved in …

The multifaceted virulence of adherent-invasive Escherichia coli

S Mansour, T Asrar, W Elhenawy - Gut Microbes, 2023 - Taylor & Francis
The surge in inflammatory bowel diseases, like Crohn's disease (CD), is alarming. While the
role of the gut microbiome in CD development is unresolved, the frequent isolation of …

Understanding HostAdherentInvasive Escherichia coli Interaction in Crohn's Disease: Opening Up New Therapeutic Strategies

A Agus, S Massier, A Darfeuille-Michaud… - BioMed research …, 2014 - Wiley Online Library
A trillion of microorganisms colonize the mammalian intestine. Most of them have coevolved
with the host in a symbiotic relationship and some of them have developed strategies to …

Antibiotics Potentiate Adherent-Invasive E. coli Infection and Expansion

AM Oberc, AA Fiebig-Comyn, CN Tsai… - Inflammatory bowel …, 2019 - academic.oup.com
Background Crohn's disease (CD) is an inflammatory bowel disease with a complex
etiology. Paradoxically, CD is associated with the use of antibiotics and with an increased …

A polymicrobial view of disease potential in Crohn's-associated adherent-invasive E. coli

W Elhenawy, A Oberc, BK Coombes - Gut microbes, 2018 - Taylor & Francis
The human gut is home to trillions of bacteria and provides the scaffold for one of the most
complex microbial ecosystems in nature. Inflammatory bowel diseases, such as Crohn's …

An adherent-invasive Escherichia coli-colonized mouse model to evaluate microbiota-targeting strategies in Crohn's disease

A Sivignon, M Chervy, C Chevarin… - Disease Models & …, 2022 - journals.biologists.com
Adherent-invasive Escherichia coli (AIEC) were investigated for their involvement in the
induction/chronicity of intestinal inflammation in Crohn's disease (CD). AIEC gut …

Characterizing the pathogenic potential of Crohn's disease-associated adherent-invasive Escherichia coli

MT Zangara, L Darwish, BK Coombes - EcoSal Plus, 2023 - Am Soc Microbiol
The microbiome of Crohn's disease (CD) patients is composed of a microbial community that
is considered dysbiotic and proinflammatory in nature. The overrepresentation of …

Host-specific adaptive diversification of Crohn's disease-associated adherent-invasive Escherichia coli

W Elhenawy, CN Tsai, BK Coombes - Cell Host & Microbe, 2019 - cell.com
Crohn's disease (CD) is an inflammatory bowel disease influenced by bacteria. Adherent-
invasive E. coli (AIEC) is associated with CD, yet the adaptations facilitating AIEC gut …