Neurodegenerative changes occurring early from primary acute immune-mediated
inflammation support the hypothesis that multiple sclerosis (MS) is a complex disease …

The damage of axons and neurons in multiple sclerosis (MS) is well recognised and
correlates with neurological disability. The reasons leading to axonal and neuronal injury …

Multiplesclerosis is a complex and heterogeneous immune-mediated disease that results in
the progressive accumulation of mental and physical symptoms. Currently approved disease …

Multiple sclerosis (MS) is the commonest cause of progressive neurological disability
amongst young, Caucasian adults. MS is considered to be an auto-immune disease that …

Multiple sclerosis (MS) is a demyelinating disease of the central nervous system that is
pathologically characterized by inflammatory demyelination and neurodegeneration. Axonal …

Historically considered to be an autoimmune demyelinating disease, multiple sclerosis is
now recognized to be characterized by significant axonal and neuronal pathology …

Introduction The pathological substrate of permanent disability in multiple sclerosis (MS) is
neuronal injury and axonal loss. While axonal loss is initiated early in the disease process …

In recent decades, the treatment approach for multiple sclerosis (MS) has experienced a
significant change. There is now a growing collection of Disease-Modifying Therapies …

The success of presently available injectable immunomodulatory therapies in treating
multiple sclerosis has led to heightened interest in finding even more efficacious and better …

Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central
nervous system (CNS) characterized by encephalitogenic leukocyte infiltration and …