The genetic architecture of common traits, including the number, frequency, and effect sizes
of inherited variants that contribute to individual risk, has been long debated. Genome-wide …

Abstract Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse
pathophysiological processes, and molecular mechanisms that are often specific to cell …

Type 2 diabetes mellitus results from the interaction of environmental factors with a
combination of genetic variants, most of which were hitherto unknown. A systematic search …

Meta-analyses of genome-wide association studies (GWAS) have identified more than 240
loci that are associated with type 2 diabetes (T2D),; however, most of these loci have been …

As with other complex diseases, unbiased association studies followed by physiological and
experimental characterization have for years formed a paradigm for identifying genes or …

We performed fine mapping of 39 established type 2 diabetes (T2D) loci in 27,206 cases
and 57,574 controls of European ancestry. We identified 49 distinct association signals at …

Protein-coding genetic variants that strongly affect disease risk can yield relevant clues to
disease pathogenesis. Here we report exome-sequencing analyses of 20,791 individuals …

To extend understanding of the genetic architecture and molecular basis of type 2 diabetes
(T2D), we conducted a meta-analysis of genetic variants on the Metabochip, including …

Abstract The Wellcome Trust Case Control Consortium (WTCCC) primary genome-wide
association (GWA) scan on seven diseases, including the multifactorial autoimmune disease …

Genome-wide association (GWA) studies have identified multiple loci at which common
variants modestly but reproducibly influence risk of type 2 diabetes (T2D),,,,,,,,,,. Established …