Major intrinsic protein or aquaporin-0 (MIP/AQP0) functions as a water channel and a cell-
junction molecule in the vertebrate eye lens. Loss of MIP function in the lens leads to …

Major intrinsic protein (MIP) is a functional water-channel (AQP0) that also plays a key role
in establishing lens fiber cell architecture. Genetic variants of MIP have been associated with …

Background The major intrinsic protein gene (MIP), also known as MIP26 or AQP0, is a
member of the water-transporting aquaporin family, which plays a critical role in the …

Purpose.: AQP0, formerly known as MIP26, likely has multiple separate functions in the
mammalian lens, including water transport, formation of thin junctions, and interactions with …

Aquaporin-0 (AQP0), a water transport channel protein, is the major intrinsic protein (MIP) of
lens fiber cell plasma membranes. Mice deficient in the gene for AQP0 (Aqp0, Mip) were …

Aquaporin 0 (AQP0) was originally characterized as a membrane intrinsic protein,
specifically expressed in the lens fibers of the ocular lens and designated MIP, for major …

Lens major intrinsic protein (MIP), exclusive to the vertebrate lens, otherwise known as
MIP26 and Aquaporin 0, is abundantly expressed as a lens fiber membrane protein …

Autosomal dominant congenital cataracts have been associated with mutations of genes
encoding several soluble and membrane proteins. By candidate gene screening, we …

Congenital cataracts are major cause of visual impairment and blindness in children and
previous studies have shown about 1/3 of non-syndromic congenital cataracts are inherited …

The PITX3 bicoid-type homeodomain transcription factor plays an important role in lens
development in vertebrates. PITX3 deficiency results in a spectrum of phenotypes from …