[HTML][HTML] Shotgun metagenomics of 250 adult twins reveals genetic and environmental impacts on the gut microbiome
The gut microbiota has been typically viewed as an environmental factor for human health.
Twins are well suited for investigating the concordance of their gut microbiomes and …
Twins are well suited for investigating the concordance of their gut microbiomes and …
[HTML][HTML] Genetic determinants of the gut microbiome in UK twins
Studies in mice and humans have revealed intriguing associations between host genetics
and the microbiome. Here we report a 16S rRNA-based analysis of the gut microbiome in …
and the microbiome. Here we report a 16S rRNA-based analysis of the gut microbiome in …
[HTML][HTML] Sub-clinical detection of gut microbial biomarkers of obesity and type 2 diabetes
Background Obesity and type 2 diabetes (T2D) are linked both with host genetics and with
environmental factors, including dysbioses of the gut microbiota. However, it is unclear …
environmental factors, including dysbioses of the gut microbiota. However, it is unclear …
Comparative metagenomics revealed commonly enriched gene sets in human gut microbiomes
K Kurokawa, T Itoh, T Kuwahara, K Oshima… - Dna …, 2007 - academic.oup.com
Numerous microbes inhabit the human intestine, many of which are uncharacterized or
uncultivable. They form a complex microbial community that deeply affects human …
uncultivable. They form a complex microbial community that deeply affects human …
[HTML][HTML] A genome-wide association study for gut metagenome in Chinese adults illuminates complex diseases
The gut microbiome has been established as a key environmental factor to health. Genetic
influences on the gut microbiome have been reported, yet, doubts remain as to the …
influences on the gut microbiome have been reported, yet, doubts remain as to the …
Organismal, genetic, and transcriptional variation in the deeply sequenced gut microbiomes of identical twins
We deeply sampled the organismal, genetic, and transcriptional diversity in fecal samples
collected from a monozygotic (MZ) twin pair and compared the results to 1,095 communities …
collected from a monozygotic (MZ) twin pair and compared the results to 1,095 communities …
[HTML][HTML] Healthy cotwins share gut microbiome signatures with their inflammatory bowel disease twins and unrelated patients
Background & aims It is currently unclear whether reported changes in the gut microbiome
are cause or consequence of inflammatory bowel disease (IBD). Therefore, we studied the …
are cause or consequence of inflammatory bowel disease (IBD). Therefore, we studied the …
[HTML][HTML] Human genetics shape the gut microbiome
Host genetics and the gut microbiome can both influence metabolic phenotypes. However,
whether host genetic variation shapes the gut microbiome and interacts with it to affect host …
whether host genetic variation shapes the gut microbiome and interacts with it to affect host …
[HTML][HTML] Interplay between the human gut microbiome and host metabolism
A Visconti, CI Le Roy, F Rosa, N Rossi… - Nature …, 2019 - nature.com
The human gut is inhabited by a complex and metabolically active microbial ecosystem.
While many studies focused on the effect of individual microbial taxa on human health, their …
While many studies focused on the effect of individual microbial taxa on human health, their …
Gut microbiome heritability is nearly universal but environmentally contingent
Relatives have more similar gut microbiomes than nonrelatives, but the degree to which this
similarity results from shared genotypes versus shared environments has been …
similarity results from shared genotypes versus shared environments has been …