Histones are well-conserved proteins that form the basic structure of chromatin in eukaryotes
and undergo several post-translational modifications, which are important for the control of …

Chagas disease, caused by Trypanosoma cruzi, still affects millions of people around the
world. No vaccines nor treatment for chronic Chagas disease are available, and …

Chromatin associated proteins are key regulators of many important processes in the cell.
Trypanosoma cruzi, a protozoa flagellate that causes Chagas disease, alternates between …

In humans and other eukaryotes, histone post-translational modifications (hPTMs) play an
essential role in the epigenetic control of gene expression. In trypanosomatid parasites …

Histones of trypanosomes are quite divergent when compared to histones of most
eukaryotes. Nevertheless, the histone H4 of Trypanosoma cruzi, the protozoan that causes …

Trypanosome histone N-terminal sequences are very divergent from the other eukaryotes,
although they are still decorated by post-translational modifications (PTMs). Here, we used a …

Histone H1 of most eukaryotes is phosphorylated during the cell cycle progression and
seems to play a role in the regulation of chromatin structure, affecting replication and …

The nuclear structure changes during the differentiation from growing to infective stages of
Trypanosoma cruzi. As histone modifications have been correlated with structural and …

Several biological processes in Trypanosoma brucei are affected by chromatin structure,
including gene expression, cell cycle regulation, and life-cycle stage differentiation. In …

Histone tails provide sites for a variety of post-translational modifications implicated in the
control of gene expression and chromatin assembly. As both histones and control of gene …