Introduction: A novel method for ultrafast and soft cold vaporization of tissue via desorption
by impulsiv e vibrational excitation (DIVE) using a picosecond-infrared laser (PIRL) has …

The analysis of proteomes directly from tissues requires the proteins to be released from the
cells and their compartments and solubilized, which usually is achieved by mechanical …

Posttranslational modifications and proteolytic processing regulate almost all physiological
processes. Dysregulation can potentially result in pathologic protein species causing …

It was recently shown that sampling of tissues with a picosecond infrared laser (PIRL) for
analysis with bottom-up proteomics is advantageous compared to mechanical …

Introduction: Human skin is the largest organ of integumentary system that protect the body
from e xternal environment and prevent excessive fluid loss [1]. Scientists are closer than …

Skin anatomy, its composition of abundant proteins, and the functions of these proteins are
greatly established and explored. The proteome including lower abundant proteins in each …

It was recently shown that ultrashort pulse infrared (IR) lasers, operating at the wavelength of
the OH vibration stretching band of water, are highly efficient for sampling and …

The prospect for spatial imaging with mass spectroscopy at the level of the cell requires new
means of cell extraction to conserve molecular structure. To this aim, we demonstrate a new …

A new concept based on the Picosecond Infrared Laser (PIRL) has been introduced to
selectively excite water to directly drive ablation of biological tissue faster than any …

DieWeiterentwicklung minimal-invasiver chirurgischer Eingriffe, räumlich aufgelöster
Massenspektrometrie und von ioanalysen mit hohem Durchsatz, bedürfen neuartiger …