Administering polymyxin antibiotics in a traditional fashion may be ineffective against Gram-
negative ESKAPE (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae …

Acinetobacter baumannii is emerging with resistance to polymyxins. In 24-h time-kill
experiments, high-dose ampicillin-sulbactam in combination with meropenem and …

Polymyxins are often last-line therapeutic agents used to treat infections caused by
multidrug-resistant A. baumannii. Recent reports of polymyxin-resistant A. baumannii …

Objectives Polymyxin B is being increasingly utilized as a last resort against resistant Gram-
negative bacteria. We examined the pharmacodynamics of novel dosing strategies for …

The emergence of polymyxin resistance in Gram-negative bacteria infections has motivated
the use of combination therapy. This study determined the mutant selection window (MSW) …

In this study, the activity of meropenem (MEM), fosfomycin (FOF) and polymyxin B (PMB),
alone and in combination, was analysed. In addition, optimisation of the pharmacodynamic …

Background Although polymyxin has been used as a last-resort antibiotic against resistant
bacteria, its use is restricted due to nephrotoxicity and neurotoxicity. While the present …

The prevalence of heteroresistant Acinetobacter baumannii is increasing. Infections due to
these resistant pathogens pose a global treatment challenge. Here, the pharmacodynamic …

Carbapenem-resistant Acinetobacter baumannii is increasing in prevalence. Polymyxin B
and tigecycline are among the most active antibiotics used against this pathogen in vitro …

The inoculum effect (ie, reduction in antimicrobial activity at large starting inoculum) is a
phenomenon described for various pathogens. Given that limited data exist regarding …