Diversity in neural firing dynamics supports both rigid and learned hippocampal sequences
AD Grosmark, G Buzsáki - Science, 2016 - science.org
Cell assembly sequences during learning are “replayed” during hippocampal ripples and
contribute to the consolidation of episodic memories. However, neuronal sequences may …
contribute to the consolidation of episodic memories. However, neuronal sequences may …
Nested sequences of hippocampal assemblies during behavior support subsequent sleep replay
Consolidation of spatial and episodic memories is thought to rely on replay of neuronal
activity sequences during sleep. However, the network dynamics underlying the initial …
activity sequences during sleep. However, the network dynamics underlying the initial …
Emergence of preconfigured and plastic time-compressed sequences in early postnatal development
When and how hippocampal neuronal ensembles first organize to support encoding and
consolidation of memory episodes, a critical cognitive function of the brain, are unknown. We …
consolidation of memory episodes, a critical cognitive function of the brain, are unknown. We …
Reactivation of experience-dependent cell assembly patterns in the hippocampus
The hippocampus is thought to be involved in episodic memory formation by reactivating
traces of waking experience during sleep. Indeed, the joint firing of spatially tuned pyramidal …
traces of waking experience during sleep. Indeed, the joint firing of spatially tuned pyramidal …
Awake hippocampal reactivations project onto orthogonal neuronal assemblies
The chained activation of neuronal assemblies is thought to support major cognitive
processes, including memory. In the hippocampus, this is observed during population bursts …
processes, including memory. In the hippocampus, this is observed during population bursts …
Superficial layers of the medial entorhinal cortex replay independently of the hippocampus
The hippocampus is thought to initiate systems-wide mnemonic processes through the
reactivation of previously acquired spatial and episodic memory traces, which can recruit the …
reactivation of previously acquired spatial and episodic memory traces, which can recruit the …
Preplay of future place cell sequences by hippocampal cellular assemblies
G Dragoi, S Tonegawa - Nature, 2011 - nature.com
During spatial exploration, hippocampal neurons show a sequential firing pattern in which
individual neurons fire specifically at particular locations along the animal's trajectory (place …
individual neurons fire specifically at particular locations along the animal's trajectory (place …
Awake hippocampal sharp-wave ripples support spatial memory
The hippocampus is critical for spatial learning and memory. Hippocampal neurons in
awake animals exhibit place field activity that encodes current location, as well as sharp …
awake animals exhibit place field activity that encodes current location, as well as sharp …
Internally generated cell assembly sequences in the rat hippocampus
A long-standing conjecture in neuroscience is that aspects of cognition depend on the
brain's ability to self-generate sequential neuronal activity. We found that reliably and …
brain's ability to self-generate sequential neuronal activity. We found that reliably and …
Hippocampal ripples down-regulate synapses
The specific effects of sleep on synaptic plasticity remain unclear. We report that mouse
hippocampal sharp-wave ripple oscillations serve as intrinsic events that trigger long-lasting …
hippocampal sharp-wave ripple oscillations serve as intrinsic events that trigger long-lasting …