Diversity in neural firing dynamics supports both rigid and learned hippocampal sequences

AD Grosmark, G Buzsáki - Science, 2016 - science.org
Cell assembly sequences during learning are “replayed” during hippocampal ripples and
contribute to the consolidation of episodic memories. However, neuronal sequences may …

Nested sequences of hippocampal assemblies during behavior support subsequent sleep replay

C Drieu, R Todorova, M Zugaro - Science, 2018 - science.org
Consolidation of spatial and episodic memories is thought to rely on replay of neuronal
activity sequences during sleep. However, the network dynamics underlying the initial …

Emergence of preconfigured and plastic time-compressed sequences in early postnatal development

U Farooq, G Dragoi - Science, 2019 - science.org
When and how hippocampal neuronal ensembles first organize to support encoding and
consolidation of memory episodes, a critical cognitive function of the brain, are unknown. We …

Reactivation of experience-dependent cell assembly patterns in the hippocampus

J O'Neill, TJ Senior, K Allen, JR Huxter… - Nature neuroscience, 2008 - nature.com
The hippocampus is thought to be involved in episodic memory formation by reactivating
traces of waking experience during sleep. Indeed, the joint firing of spatially tuned pyramidal …

Awake hippocampal reactivations project onto orthogonal neuronal assemblies

A Malvache, S Reichinnek, V Villette, C Haimerl… - Science, 2016 - science.org
The chained activation of neuronal assemblies is thought to support major cognitive
processes, including memory. In the hippocampus, this is observed during population bursts …

Superficial layers of the medial entorhinal cortex replay independently of the hippocampus

J O'Neill, CN Boccara, F Stella, P Schönenberger… - Science, 2017 - science.org
The hippocampus is thought to initiate systems-wide mnemonic processes through the
reactivation of previously acquired spatial and episodic memory traces, which can recruit the …

Preplay of future place cell sequences by hippocampal cellular assemblies

G Dragoi, S Tonegawa - Nature, 2011 - nature.com
During spatial exploration, hippocampal neurons show a sequential firing pattern in which
individual neurons fire specifically at particular locations along the animal's trajectory (place …

Awake hippocampal sharp-wave ripples support spatial memory

SP Jadhav, C Kemere, PW German, LM Frank - Science, 2012 - science.org
The hippocampus is critical for spatial learning and memory. Hippocampal neurons in
awake animals exhibit place field activity that encodes current location, as well as sharp …

Internally generated cell assembly sequences in the rat hippocampus

E Pastalkova, V Itskov, A Amarasingham, G Buzsaki - Science, 2008 - science.org
A long-standing conjecture in neuroscience is that aspects of cognition depend on the
brain's ability to self-generate sequential neuronal activity. We found that reliably and …

Hippocampal ripples down-regulate synapses

H Norimoto, K Makino, M Gao, Y Shikano, K Okamoto… - Science, 2018 - science.org
The specific effects of sleep on synaptic plasticity remain unclear. We report that mouse
hippocampal sharp-wave ripple oscillations serve as intrinsic events that trigger long-lasting …