Translational readthrough gives rise to C-terminally extended proteins, thereby providing the
cell with new protein isoforms. These may have different properties from the parental …

Translational readthrough gives rise to low abundance proteins with C-terminal extensions
beyond the stop codon. To identify functional translational readthrough, we estimated the …

The first crystal structure of the human cytosolic malate dehydrogenase I (MDH1) is
described. Structure determination at a high resolution (1.65 Å) followed production …

Context Genes causing familial forms of diabetes mellitus are only partially known. Objective
We set out to identify the genetic cause of hyperglycemia in multigenerational families with …

Translation of mRNA into a polypeptide chain is a highly accurate process. Many prokaryotic
and eukaryotic viruses, however, use leaky termination of translation to optimize their coding …

Malate dehydrogenase (MDH) is an enzyme widely distributed among living organisms and
is a key protein in the central oxidative pathway. It catalyzes the interconversion between …

Background The family of D-isomer specific 2-hydroxyacid dehydrogenases (2HADHs)
contains a wide range of oxidoreductases with various metabolic roles as well as …

Abstract Lactate dehydrogenase (LDH, EC. 1.1. 127) is an important enzyme engaged in the
anaerobic metabolism of cells, catalyzing the conversion of pyruvate to lactate and NADH to …

The NAD (P)-dependent malate dehydrogenases (MDH)(EC 1.1. 1.37) and NAD-dependent
lactate dehydrogenases (LDH)(EC. 1.1. 1.27) form a large superfamily that has been …

Malate and lactate dehydrogenases (MDH and LDH) are homologous, core metabolic
enzymes that share a fold and catalytic mechanism yet possess strict specificity for their …