Identifying N-Glycan Biomarkers in Colorectal Cancer by Mass Spectrometry

MK Sethi, WS Hancock, S Fanayan - Accounts of chemical …, 2016 - ACS Publications
Conspectus Colorectal cancer (CRC) is one of the most prevalent cancers worldwide.
Delineating biological markers (biomarkers) for early detection, when treatment is most …

[HTML][HTML] Profound diversity of the N-glycome from microdissected regions of colorectal cancer, stroma, and normal colon mucosa

D Wang, K Madunić, T Zhang… - Engineering, 2023 - Elsevier
Aberrant glycosylation is considered to be a hallmark of colorectal cancer (CRC), as
demonstrated by various studies. While the N-glycosylation of cell lines and serum has been …

In-depth N-glycome profiling of paired colorectal cancer and non-tumorigenic tissues reveals cancer-, stage- and EGFR-specific protein N-glycosylation

MK Sethi, H Kim, CK Park, MS Baker, YK Paik… - …, 2015 - academic.oup.com
Glycomics may assist in uncovering the structure–function relationships of protein
glycosylation and identify glycoprotein markers in colorectal cancer (CRC) research. Herein …

[HTML][HTML] N-glycomic profiling of colorectal cancer according to tumor stage and location

M Holm, P Nummela, A Heiskanen, T Satomaa… - PLoS …, 2020 - journals.plos.org
Alterations in glycosylation are seen in many types of cancer, including colorectal cancer
(CRC). Glycans, the sugar moieties of glycoconjugates, are involved in many important …

[HTML][HTML] N-glycomic profiling as a tool to separate rectal adenomas from carcinomas

T Kaprio, T Satomaa, A Heiskanen, CH Hokke… - Molecular & Cellular …, 2015 - ASBMB
All human cells are covered by glycans, the carbohydrate units of glycoproteins, glycolipids,
and proteoglycans. Most glycans are localized to cell surfaces and participate in events …

[HTML][HTML] N-glycosylation of colorectal cancer tissues: a liquid chromatography and mass spectrometry-based investigation

CIA Balog, K Stavenhagen, WLJ Fung… - Molecular & Cellular …, 2012 - ASBMB
Colorectal cancer is the third most common cancer worldwide with an annual incidence of∼
1 million cases and an annual mortality rate of∼ 655,000 individuals. There is an urgent …

[HTML][HTML] Mass Spectrometry-Based N-Glycomics of Colorectal Cancer

MK Sethi, S Fanayan - International journal of molecular sciences, 2015 - mdpi.com
Colorectal cancer (CRC) is one of the most prevalent cancers worldwide. An increased
molecular understanding of the CRC pathology is warranted to gain insights into the …

[HTML][HTML] Identification of differential N-glycan compositions in the serum and tissue of colon cancer patients by mass spectrometry

MMA Coura, EA Barbosa, GD Brand, C Bloch Jr… - Biology, 2021 - mdpi.com
Simple Summary Incidence of colorectal cancer (CRC) has been rising in Brazil. To date, no
reliable biomarker has been described in CRC for diagnosis and prognosis. Modifications in …

[HTML][HTML] High-Mannose N-Glycans as Malignant Progression Markers in Early-Stage Colorectal Cancer

F Boyaval, H Dalebout, R Van Zeijl, W Wang… - Cancers, 2022 - mdpi.com
Simple Summary The detection of colorectal cancer (CRC) at an early stage is increasing
due to the implementation of screening programs. Local excision of early CRC is potentially …

[HTML][HTML] Trends in oligomannosylation and α1, 2-mannosidase expression in human cancers

S Chatterjee, J Ugonotti, LY Lee, A Everest-Dass… - Oncotarget, 2021 - ncbi.nlm.nih.gov
Aberrant protein glycosylation is a prominent cancer feature. While many tumour-associated
glycoepitopes have been reported, advances in glycoanalytics continue to uncover new …