Oral administration of d-galactose induces cognitive impairments and oxidative damage in rats
Abstract d-Galactose (d-gal) is a reducing sugar that can be used to mimic the
characteristics of aging in rodents; however, the effects of d-gal administration by oral route …
characteristics of aging in rodents; however, the effects of d-gal administration by oral route …
The influence of gender, age and treatment time on brain oxidative stress and memory impairment induced by D-galactose in mice
L Hao, H Huang, J Gao, C Marshall, Y Chen, M Xiao - Neuroscience letters, 2014 - Elsevier
Chronic exposure to d-galactose (d-gal) serves as a model for age-related oxidative
damage and cognitive dysfunction. However, methods used, including the dose and …
damage and cognitive dysfunction. However, methods used, including the dose and …
A high dose of short term exogenous D-galactose administration in young male rats produces symptoms simulating the natural aging process
Aims d-Galactose (d-gal) induced accelerated senescence has been used to develop an
aging model for brain. Previously, long term administration of a wide range of doses has …
aging model for brain. Previously, long term administration of a wide range of doses has …
[HTML][HTML] Evaluation of acute and chronic effects of D-galactose on memory and learning in Wistar rats
B Chogtu, A Arivazhahan, SK Kunder… - Clinical …, 2018 - ncbi.nlm.nih.gov
Objective D-galactose has been commonly used in rodent models to induce accelerated
effects of aging, including those on learning, memory, and muscular tone and coordination …
effects of aging, including those on learning, memory, and muscular tone and coordination …
Differential impairment of spatial and nonspatial cognition in a mouse model of brain aging
W Wang, S Li, H Dong, S Lv, Y Tang - Life sciences, 2009 - Elsevier
AIMS: Chronic exposure to d-galactose (D-Gal), which causes acceleration in aging and
simulated symptoms of natural senescence, has been used as a reliable animal model of …
simulated symptoms of natural senescence, has been used as a reliable animal model of …
Folic acid prevents habituation memory impairment and oxidative stress in an aging model induced by D-galactose
ML Garcez, RCS Cassoma, F Mina… - Metabolic Brain …, 2021 - Springer
The present study aimed to evaluate the effect of folic acid treatment in an animal model of
aging induced by D-galactose (D-gal). For this propose, adult male Wistar rats received D …
aging induced by D-galactose (D-gal). For this propose, adult male Wistar rats received D …
The oral administration of D-galactose induces abnormalities within the mitochondrial respiratory chain in the brain of rats
Abstract D-Galactose (D-gal) chronic administration via intraperitoneal and subcutaneous
routes has been used as a model of aging and Alzheimer disease in rodents. Intraperitoneal …
routes has been used as a model of aging and Alzheimer disease in rodents. Intraperitoneal …
Behavioural study of the D-galactose induced aging model in C57BL/6J mice
H Wei, L Li, Q Song, H Ai, J Chu, W Li - Behavioural brain research, 2005 - Elsevier
Rodent chronically injected with d-galactose (d-gal) has been used as an animal aging
model for brain aging or anti-aging pharmacology research. However, the dosage of d-gal …
model for brain aging or anti-aging pharmacology research. However, the dosage of d-gal …
Chronic systemic D‐galactose exposure induces memory loss, neurodegeneration, and oxidative damage in mice: Protective effects of R‐α‐lipoic acid
XU Cui, P Zuo, Q Zhang, X Li, Y Hu… - Journal of …, 2006 - Wiley Online Library
Chronic systemic exposure of D‐galactose to mice, rats, and Drosophila causes the
acceleration of senescence and has been used as an aging model. However, the underlying …
acceleration of senescence and has been used as an aging model. However, the underlying …
Chronic D-galactose administration induces natural aging characteristics, in rat's brain and heart
P Pantiya, C Thonusin, B Ongnok, T Chunchai… - Toxicology, 2023 - Elsevier
We aimed to investigate the effect of chronic D-galactose exposure on the mimicking of
natural aging processes based upon the hallmarks of aging. Seven-week-old male Wistar …
natural aging processes based upon the hallmarks of aging. Seven-week-old male Wistar …