Insulin resistance and the metabolic syndrome are complex metabolic traits and key risk
factors for the development of cardiovascular disease. They result from the interplay of …

Insulin resistance underpins the link between obesity and most of its associated metabolic
disorders including type 2 diabetes, fatty liver disease, dyslipidaemia and cardiovascular …

Recent genome-wide association studies have described many loci implicated in type 2
diabetes (T2D) pathophysiology and β-cell dysfunction but have contributed little to the …

Insulin resistance is part of a metabolic syndrome that also includes non–insulin-dependent
diabetes mellitus, dyslipidemia, obesity, and hypertension. It has been hypothesized that …

As obesity and diabetes reach epidemic proportions in the developed world, the role of
insulin resistance and its consequences are gaining prominence. Understanding the role of …

Insulin resistance (IR) is a well-established risk factor for metabolic disease. The ratio of
triglycerides to high-density lipoprotein cholesterol (TG: HDL-C) is a surrogate marker of IR …

Insulin resistance often occurs with dyslipidemia as part of the metabolic syndrome and the
current dominant paradigm is that insulin resistance leads to dyslipidemia. However …

Both type 2 diabetes mellitus (T2DM) and insulin resistance are complex traits in which
multiple gene effects and metabolic and environmental factors combine to contribute to the …

Insulin resistance is common and plays a central role in the pathogenesis of type 2 diabetes
mellitus (T2DM). Precedents in biomedical research indicate that evaluation of monogenic …

Our understanding of the genetics of type 2 diabetes mellitus (T2DM) has changed, in part
owing to implementation of genome-wide association studies as a method for unraveling the …