In this chapter, the contributions of cells in the immune system (monocyte-macrophages,
myeloid derived suppressor cells, mesenchymal stromal cells, T cell subsets, NK cells …

Publisher Summary Osteoimmunology in the context of multiple myeloma is a newly
emerging field, and it is clear that interactions between myeloma cells and cells of the …

It has been over 25 years since the first observations that cells of the immune system could
influence the functions of bone cells. Since that time, significant strides have been made in …

Metastases to bone occur in about 70% of patients with metastatic prostate and breast
cancers. Unfortunately, bone metastases result in significant morbidity and mortality and …

Publisher Summary Tumors have multiple effects on the skeleton, all of which are mediated
by tumor cells altering the behavior of bone cells and causing disruptions or enhancement of …

Multiple myeloma develops and expands almost exclusively in the bone marrow, and
generates devastating bone destruction. MM cells produce a variety of cytokines to stimulate …

The bone is one of the most frequently affected organs for cancer metastasis. Bone
destruction is a hallmark of bone metastasis, osteolytic primary bone tumors, and …

Bone metastases are frequent and debilitating consequence for many tumors, such as
breast, lung, prostate, and kidney cancer. Many studies report the importance of the immune …

Bone is a common site for metastasis from a large number of malignancies and other tumors
such as osteosarcoma originate in this tissue. Bone constitutes a unique environment that …

Lymphocytes are implicated in the pathogenesis of bone disease in chronic inflammation,
osteoporosis, transplantation and osteopetrosis. The effects of lymphocytes and lymphocyte …