Background The first clues to the process of gamete activation date back to nearly 60 years
ago. The mutual activation of gametes is a crucial event during fertilization. In the testis and …

In the mouse and other mammals studied, including man, ejaculated spermatozoa cannot
immediately fertilize an egg. They require a certain period of residence in the female genital …

Precise control of mammalian oogenesis has been a traditional focus of reproductive and
developmental biology research. Recently, new reports have introduced the possibility of …

After ejaculation, mammalian sperm have not yet acquired full fertilising capacity. They will
require a finite period of residence in the female reproductive tract before they become …

Intensive study over the past 10 years has resulted in major advances in our understanding
of the signalling mechanisms required for the transformation of the oocyte into an embryo …

Following intracytoplasmic sperm injection (ICSI), some patients present low or zero
fertilization rates. Artificial oocyte activation has been proposed as a suitable means to …

Stem cell-based strategies for ovarian regeneration and oocyte production have been
proposed as future clinical therapies for treating infertility in women. However, utilization of …

Disruptive reproductive technologies | Science Translational Medicine news careers commentary
Journals Science Science brought to you byGoogle Indexer Log in science science advances …

Mammalian sperm must spend a minimum period of time within a female reproductive tract
to achieve the capacity to fertilize oocytes. This phenomenon, termed sperm 'capacitation' …

After ejaculation, the mammalian male gamete must undergo the capacitation process,
which is a prerequisite for egg fertilization. The bioenergetics of sperm capacitation is poorly …