Abstract Methylation at 5-cytosine (5-mC) is a fundamental epigenetic DNA modification
associated recently with cardiac disease. In contrast, the role of 5-hydroxymethylcytosine (5 …

The heart is a highly specialized organ with essential function for the organism throughout
life. The significance of DNA methylation in shaping the phenotype of the heart remains only …

Abstract DNA 5-hydroxymethylcytosine (5hmC) modification is known to be associated with
gene transcription and frequently used as a mark to investigate dynamic DNA methylation …

cAMP is a highly regulated secondary messenger involved in many biological processes.
Chronic activation of the cAMP pathway by catecholamines results in cardiac hypertrophy …

Epigenetic alterations are implicated in the development of cardiac hypertrophy and heart
failure, but little is known of which epigenetic changes in which regions of the genome play …

Background: N 6-Methyladenosine (m6A) methylation is the most prevalent internal
posttranscriptional modification on mammalian mRNA. The role of m6A mRNA methylation …

Relatively little is known about the epigenetic control mechanisms that guide postnatal
organ maturation. The goal of this study was to determine whether DNA methylation plays …

Background: Correct gene expression programming of the cardiomyocyte underlies the
normal functioning of the heart. Alterations to this can lead to the loss of cardiac …

Background DNA methylation is a major epigenetic mechanism altering gene expression in
development and disease. However, its role in the regulation of gene expression during …

Myogenic cell cultures derived from muscle biopsies are excellent models for human cell
differentiation. We report the first comprehensive analysis of myogenesis-specific DNA hyper …