Diagnoses that are both timely and accurate are critically important for patients with life-
threatening or drug resistant infections. Technological improvements in High-Throughput …

Discussion These cases, which represent the first use of real-time metagenomic sequencing
to identify pathogens in pneumonia, demonstrate the enormous potential of rapid …

Rapid and accurate pathogen identification is necessary for appropriate treatment of
pneumonia. Here, we describe the use of shotgun metagenomic next-generation …

Pulmonary infections are among the most common and important infectious diseases due to
their high morbidity and mortality, especially in older and immunocompromised individuals …

Background Metagenomic sequencing of respiratory microbial communities for pathogen
identification in pneumonia may help overcome the limitations of culture-based methods. We …

High throughput sequencing has been proposed as a one-stop solution for diagnostics and
molecular typing directly from patient samples, allowing timely and appropriate …

Introduction Rapid and accurate pathogen identification is essential for the treatment of
pneumonia. Metagenomic next‐generation sequencing (mNGS) is a newly developed …

Background The diagnosis of bacterial pathogens in lower respiratory tract infections (LRI)
using conventional culture methods remains challenging and time-consuming. Objectives …

Metagenomic sequencing is frequently claimed to have the potential to revolutionize
microbiology through rapid species identification and antimicrobial resistance (AMR) …

Etiologic diagnosis of bacterial pneumonia relies on identification of causative pathogens by
cultures, which require extended incubation periods and have limited sensitivity. Next …