Despite major improvements in the treatment of patients with diabetes mellitus, many
patients still suffer from progressive diabetic kidney disease. More research is needed to …

Although diabetic kidney disease (DKD) is the most common cause of end-stage kidney
disease worldwide, the pathogenic mechanisms are poorly understood. There is increasing …

Mitochondrial dysfunction is implicated in the pathogenesis of diabetic kidney disease
(DKD). Compared to the vast body of evidence from preclinical in vitro and in vivo studies …

Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease (ESRD) in
the United States and many other countries. DKD occurs through a variety of pathogenic …

Globally, diabetes is the leading cause of chronic kidney disease and end-stage renal
disease, which are major risk factors for cardiovascular disease and death. Despite this …

The role and nature of mitochondrial dysfunction in diabetic kidney disease (DKD) has been
extensively studied. Yet, the molecular drivers of mitochondrial remodeling in DKD are …

The underlying mechanisms in the development of diabetic nephropathy are currently
unclear and likely consist of a series of dynamic events from the early to late stages of the …

The role of mitochondria in diabetic complications has been viewed as a source of excess
superoxide production leading to cell dysfunction. However, with the lack of benefit of non …

The kidneys are highly metabolic organs that produce vast quantities of adenosine
triphosphate via oxidative phosphorylation and, as such, contain many mitochondria …

Diabetic kidney disease (DKD) is the leading cause of end stage renal disease (ESRD) in
the USA. The pathogenesis of DKD is multifactorial and involves activation of multiple …