Phenotypes of prediabetes and stratification of cardiometabolic risk

N Stefan, A Fritsche, F Schick… - The lancet Diabetes & …, 2016 - thelancet.com
Prediabetes is associated with increased risks of type 2 diabetes, cardiovascular disease,
dementia, and cancer, and its prevalence is increasing worldwide. Lifestyle and …

Prediabetes: a high-risk state for diabetes development

AG Tabák, C Herder, W Rathmann, EJ Brunner… - The Lancet, 2012 - thelancet.com
Prediabetes (intermediate hyperglycaemia) is a high-risk state for diabetes that is defined by
glycaemic variables that are higher than normal, but lower than diabetes thresholds. 5–10 …

Pathophysiology-based subphenotyping of individuals at elevated risk for type 2 diabetes

R Wagner, M Heni, AG Tabak, J Machann, F Schick… - Nature medicine, 2021 - nature.com
The state of intermediate hyperglycemia is indicative of elevated risk of developing type 2
diabetes. However, the current definition of prediabetes neither reflects subphenotypes of …

Definition of intervention points in prediabetes

E Ferrannini - The lancet Diabetes & endocrinology, 2014 - thelancet.com
With respect to clinical phenotype and pathophysiology, prediabetes is akin to diabetes.
Prediabetes is prevalent in the global population, and those affected are at high risk of …

Lifetime risk of developing impaired glucose metabolism and eventual progression from prediabetes to type 2 diabetes: a prospective cohort study

S Ligthart, TTW van Herpt, MJG Leening… - The lancet Diabetes & …, 2016 - thelancet.com
Background Data are scarce for the lifetime risk of developing impaired glucose metabolism,
including prediabetes, as are data for the risk of eventual progression from prediabetes to …

[HTML][HTML] Prediabetes: a high-risk state for developing diabetes

AG Tabák, C Herder, W Rathmann, EJ Brunner… - Lancet, 2012 - ncbi.nlm.nih.gov
Summary Prediabetes (or “intermediate hyperglycaemia”), based on glycaemic parameters
above normal but below diabetes thresholds is a high risk state for diabetes with an …

Metabolic health and cardiometabolic risk clusters: implications for prediction, prevention, and treatment

N Stefan, MB Schulze - The lancet Diabetes & endocrinology, 2023 - thelancet.com
Among 20 leading global risk factors for years of life lost in 2040, reference forecasts point to
three metabolic risks—high blood pressure, high BMI, and high fasting plasma glucose—as …

Approaching pre-diabetes

L Perreault, K Færch - Journal of Diabetes and its Complications, 2014 - Elsevier
As the global epidemic of type 2 diabetes continues to rise, the time has come to revisit our
approach to pre-diabetes. Recently, much ado has been made about screening, diagnosis …

Treating prediabetes: why and how should we do it?

T Braga, LG Kraemer-Aguiar, NG Docherty… - Minerva …, 2018 - europepmc.org
Prediabetes is the subclinical impairment in fasting plasma glucose, impaired glucose
tolerance or both. The degree of impairment is between euglycemia and the hyperglycemia …

Prediabetes in youths: mechanisms and biomarkers

R Weiss, N Santoro, C Giannini, A Galderisi… - The lancet child & …, 2017 - thelancet.com
Obesity has been estimated to decrease life expectancy by as little as 0· 8 years to as much
as 7 years, and is the second leading cause of preventable death—after smoking—in the …