Background Amyotrophic lateral sclerosis (ALS) is a fatal progressive neurodegenerative
disease with no available therapy. Components of the innate immune system are activated …

Complement activation products are elevated in cerebrospinal fluid, spinal cord and motor
cortex of patients with amyotrophic lateral sclerosis (ALS) but are untested in models. We …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease, characterized by
the progressive loss of motor neurons within the central nervous system. Neural …

Amyotrophic lateral sclerosis (ALS) is a fatal and rapidly progressing motor neuron disease
without effective treatment. Although the precise mechanisms leading to ALS are yet to be …

Background Components of the innate immune complement system have been implicated in
the pathogenesis of amyotrophic lateral sclerosis (ALS); however, a comprehensive …

Complement activation products are elevated in the cerebrospinal fluid and spinal cord of
patients with amyotrophic lateral sclerosis (ALS). In this study, we demonstrate complement …

Background Components of the innate immune complement system have been implicated in
the pathogenesis of amyotrophic lateral sclerosis (ALS) specifically using hSOD1 transgenic …

Background Increasing evidence suggests that the immune system has a beneficial role in
the progression of amyotrophic lateral sclerosis (ALS) although the mechanism remains …

Increasing evidence suggests a role for the immune system in amyotrophic lateral sclerosis
(ALS). To determine the extent of the immune activation in ALS we analyzed the expression …

Amyotrophic lateral sclerosis (ALS) is a devastating progressive neurodegenerative disease
affecting primarily the upper and lower motor neurons. A common feature of all ALS cases is …