Recent progress in genetic and epigenetic research on type 2 diabetes

SH Kwak, KS Park - Experimental & molecular medicine, 2016 - nature.com
Abstract Type 2 diabetes (T2DM) is a common complex metabolic disorder that has a strong
genetic predisposition. During the past decade, progress in genetic association studies has …

The search for genetic risk factors of type 2 diabetes mellitus

KS Park - Diabetes & metabolism journal, 2011 - synapse.koreamed.org
Type 2 diabetes mellitus (T2DM) is caused by complex interplay between multiple genetic
and environmental factors. The three major approaches used to identify the genetic …

[HTML][HTML] DNA methylation in the pathogenesis of type 2 diabetes in humans

C Davegårdh, S García-Calzón, K Bacos, C Ling - Molecular metabolism, 2018 - Elsevier
Abstract Background Type 2 diabetes (T2D) is a multifactorial, polygenic disease caused by
impaired insulin secretion and insulin resistance. Genome-wide association studies (GWAS) …

The role of DNA methylation in the pathogenesis of type 2 diabetes mellitus

SAH Ahmed, SA Ansari, EPK Mensah-Brown… - Clinical …, 2020 - Springer
Diabetes mellitus (DM) is a chronic condition characterised by β cell dysfunction and
persistent hyperglycaemia. The disorder can be due to the absence of adequate pancreatic …

Genetics of type 2 diabetes—pitfalls and possibilities

RB Prasad, L Groop - Genes, 2015 - mdpi.com
Type 2 diabetes (T2D) is a complex disease that is caused by a complex interplay between
genetic, epigenetic and environmental factors. While the major environmental factors, diet …

Genetics of type 2 diabetes

E Ahlqvist, TS Ahluwalia, L Groop - Clinical chemistry, 2011 - academic.oup.com
BACKGROUND Type 2 diabetes (T2D) is a complex disorder that is affected by multiple
genetic and environmental factors. Extensive efforts have been made to identify the disease …

DNA methylation profiling identifies epigenetic dysregulation in pancreatic islets from type 2 diabetic patients

M Volkmar, S Dedeurwaerder, DA Cunha… - The EMBO …, 2012 - embopress.org
In addition to genetic predisposition, environmental and lifestyle factors contribute to the
pathogenesis of type 2 diabetes (T2D). Epigenetic changes may provide the link for …

Rare and common genetic events in type 2 diabetes: what should biologists know?

A Bonnefond, P Froguel - Cell metabolism, 2015 - cell.com
Type 2 diabetes (T2D) had long been referred to as the" geneticist's nightmare." Genome-
wide association studies have fully confirmed the polygenic nature of T2D, demonstrating …

Type 2 diabetes-associated genetic polymorphisms as potential disease predictors

BZ Witka, DJ Oktaviani, M Marcellino… - … syndrome and obesity …, 2019 - Taylor & Francis
Diabetes is a major cause of mortality worldwide. There are several types of diabetes, with
type 2 diabetes mellitus (T2DM) being the most common. Many factors, including …

[HTML][HTML] Type 2 diabetes genetics: beyond GWAS

DK Sanghera, PR Blackett - Journal of diabetes & metabolism, 2012 - ncbi.nlm.nih.gov
The global epidemic of type 2 diabetes mellitus (T2D) is one of the most challenging
problems of the 21 st century leading cause of and the fifth death worldwide. Substantial …