[HTML][HTML] Apolipoprotein E4 causes age-dependent disruption of slow gamma oscillations during hippocampal sharp-wave ripples
Apolipoprotein (apo) E4 is the major genetic risk factor for Alzheimer's disease (AD), but the
mechanism by which it causes cognitive decline is unclear. In knockin (KI) mice, human …
mechanism by which it causes cognitive decline is unclear. In knockin (KI) mice, human …
[HTML][HTML] Early hippocampal sharp-wave ripple deficits predict later learning and memory impairments in an Alzheimer's disease mouse model
Alzheimer's disease (AD) is characterized by progressive memory loss, and there is a
pressing need to identify early pathophysiological alterations that predict subsequent …
pressing need to identify early pathophysiological alterations that predict subsequent …
Apolipoprotein E4 causes age-and Tau-dependent impairment of GABAergic interneurons, leading to learning and memory deficits in mice
Y Andrews-Zwilling, N Bien-Ly, Q Xu, G Li… - Journal of …, 2010 - Soc Neuroscience
Apolipoprotein E4 (apoE4) is the major genetic risk factor for Alzheimer's disease. However,
the underlying mechanisms are unclear. We found that female apoE4 knock-in (KI) mice had …
the underlying mechanisms are unclear. We found that female apoE4 knock-in (KI) mice had …
[HTML][HTML] Apolipoprotein E4 causes age-and sex-dependent impairments of hilar GABAergic interneurons and learning and memory deficits in mice
L Leung, Y Andrews-Zwilling, SY Yoon, S Jain, K Ring… - PloS one, 2012 - journals.plos.org
Apolipoprotein (apo) E4 is the major genetic risk factor for Alzheimer's disease (AD). ApoE4
has sex-dependent effects, whereby the risk of developing AD is higher in apoE4 …
has sex-dependent effects, whereby the risk of developing AD is higher in apoE4 …
[HTML][HTML] Neuronal hyperactivity due to loss of inhibitory tone in APOE4 mice lacking Alzheimer's disease-like pathology
The ε4 allele of apolipoprotein E (APOE) is the dominant genetic risk factor for late-onset
Alzheimer's disease (AD). However, the reason APOE4 is associated with increased AD risk …
Alzheimer's disease (AD). However, the reason APOE4 is associated with increased AD risk …
Differential signaling mediated by ApoE2, ApoE3, and ApoE4 in human neurons parallels Alzheimer's disease risk
YWA Huang, B Zhou, AM Nabet, M Wernig… - Journal of …, 2019 - Soc Neuroscience
In blood, apolipoprotein E (ApoE) is a component of circulating lipoproteins and mediates
the clearance of these lipoproteins from blood by binding to ApoE receptors. Humans …
the clearance of these lipoproteins from blood by binding to ApoE receptors. Humans …
APOEε4 associates with microglial activation independently of Aβ plaques and tau tangles
Animal studies suggest that the apolipoprotein E ε4 (APOE ε4) allele is a culprit of early
microglial activation in Alzheimer's disease (AD). Here, we tested the association between …
microglial activation in Alzheimer's disease (AD). Here, we tested the association between …
APOE ε4 worsens hippocampal CA1 apical neuropil atrophy and episodic memory
GA Kerchner, D Berdnik, JC Shen, JD Bernstein… - Neurology, 2014 - AAN Enterprises
Objectives: Using high-resolution structural MRI, we endeavored to study the relationships
among APOE ε4, hippocampal subfield and stratal anatomy, and episodic memory …
among APOE ε4, hippocampal subfield and stratal anatomy, and episodic memory …
Apolipoprotein E4 produced in GABAergic interneurons causes learning and memory deficits in mice
J Knoferle, SY Yoon, D Walker, L Leung… - Journal of …, 2014 - Soc Neuroscience
Apolipoprotein (apo) E4 is expressed in many types of brain cells, is associated with age-
dependent decline of learning and memory in humans, and is the major genetic risk factor …
dependent decline of learning and memory in humans, and is the major genetic risk factor …
Peripheral apoE4 enhances Alzheimer's pathology and impairs cognition by compromising cerebrovascular function
The ε4 allele of the apolipoprotein E (APOE) gene, a genetic risk factor for Alzheimer's
disease, is abundantly expressed in both the brain and periphery. Here, we present …
disease, is abundantly expressed in both the brain and periphery. Here, we present …