Systematic studies of cancer genomes have provided unprecedented insights into the
molecular nature of cancer. Using this information to guide the development and application …

Obtaining accurate drug response data in large cohorts of cancer patients is very
challenging; thus, most cancer pharmacogenomics discovery is conducted in preclinical …

Background Human cancer cell line profiling and drug sensitivity studies provide valuable
information about the therapeutic potential of drugs and their possible mechanisms of action …

Background Personalized therapy provides the best outcome of cancer care and its
implementation in the clinic has been greatly facilitated by recent convergence of enormous …

Current efforts in precision oncology largely focus on the benefit of genomics-guided
therapy. Yet, advances in sequencing techniques provide an unprecedented view of the …

Background The molecular mechanisms underlying innate tumor drug resistance, a major
obstacle to successful cancer therapy, remain poorly understood. In colorectal cancer …

Large efforts dedicated to detect somatic alterations across tumor genomes/exomes are
expected to produce significant improvements in precision cancer medicine. However, high …

Somatic genetic alterations in cancers have been linked with response to targeted
therapeutics by creation of specific dependency on activated oncogenic signaling pathways …

Background Large-sequencing cancer genome projects have shown that tumors have
thousands of molecular alterations and their frequency is highly heterogeneous. In such …

Recent discoveries of genomic alterations that underlie and promote the malignant
phenotype, together with an expanded repertoire of targeted agents, have provided many …