The serine/threonine protein kinase, TBK1, plays a crucial role as the hub for many innate
immune signaling pathways that lead to the induction of type I interferon (IFN) and interferon …

Abstract TANK-binding kinase 1 (TBK1) is a serine/threonine protein kinase that plays a
crucial role in innate immunity. Enhanced TBK1 function is associated with autoimmune …

The serine/threonine protein kinase TBK1 (Tank-binding Kinase-1) is a noncanonical
member of the IkB kinase (IKK) family. This kinase regulates signaling pathways in innate …

Introduction: TANK-binding kinase 1 (TBK1) is a noncanonical IκB kinase family member
that regulates the innate immune response. Misregulation of TBK1 activity can promote …

The pathogenesis of autoimmune diseases, such as rheumatoid arthritis (RA) and systemic
lupus erythematosus (SLE) is driven by genetic predisposition and environmental triggers …

Objective Upregulation of type I interferons (IFN-I) is a hallmark of systemic autoimmune
diseases like primary Sjögren's syndrome (pSS), systemic lupus erythematosus (SLE) and …

Inflammation is a complex biological response of tissues to harmful stimuli such as
pathogens, cell damage, or irritants. Inflammation is considered to be a major cause of most …

TANK-binding kinase 1 (TBK1) serves as a key convergence point in multiple innate
immune signaling pathways. In response to receptor-mediated pathogen detection, TBK1 …

Since the original identification of Bruton's tyrosine kinase (BTK) as the gene defective in the
primary immunodeficiency X-linked agammaglobulinemia (XLA) in 1993, our knowledge on …

Dendritic cells (DCs) are crucial for mediating immune responses but, when deregulated,
also contribute to immunological disorders, such as autoimmunity. The molecular …