L-carnitine supplementation for the management of fatigue in patients with hypothyroidism on levothyroxine treatment: a randomized, double-blind, placebo-controlled …

JH An, YJ Kim, KJ Kim, SH Kim, NH Kim, HY Kim… - Endocrine …, 2016 - jstage.jst.go.jp
Hypothyroid patients experience fatigue-related symptoms despite adequate thyroid
hormone replacement. Thyroid hormone plays an essential role in carnitine-dependent fatty …

[HTML][HTML] Association between fatigue, peripheral serotonin, and L-carnitine in hypothyroidism and in chronic fatigue syndrome

T Raij, K Raij - Frontiers in Endocrinology, 2024 - frontiersin.org
Background Fatigue of unknown origin is a hallmark symptom in chronic fatigue syndrome
(CFS) and is also found in 20% of hypothyroidism patients despite appropriate levothyroxine …

[HTML][HTML] Safety, tolerability and symptom outcomes associated with L-carnitine supplementation in patients with cancer, fatigue, and carnitine deficiency: a phase I/II …

RA Cruciani, E Dvorkin, P Homel, S Malamud… - Journal of pain and …, 2006 - Elsevier
Carnitine deficiency is among the many metabolic disturbances that may contribute to
fatigue in patients with cancer. Administration of exogenous l-carnitine may hold promise as …

L-carnitine supplementation for the management of fatigue in patients with cancer: an eastern cooperative oncology group phase III, randomized, double-blind …

RA Cruciani, JJ Zhang, J Manola, D Cella… - Journal of clinical …, 2012 - ascopubs.org
Purpose L-carnitine, a popular complementary and alternative medicine product, is used by
patients with cancer for the treatment of fatigue, the most commonly reported symptom in this …

L‐carnitine supplementation for the treatment of fatigue and depressed mood in cancer patients with carnitine deficiency: a preliminary analysis

RA Cruciani, E Dvorkin, P Homel… - Annals of the New …, 2004 - Wiley Online Library
Nutritional factors are among the postulated causes of fatigue, a highly prevalent symptom in
the cancer population, with serious impact on patients' quality of life. Deficiency of the …

[HTML][HTML] L-Carnitine supplementation reduces the general fatigue of cancer patients during chemotherapy

H Matsui, T Einama, S Shichi… - Molecular and …, 2018 - spandidos-publications.com
L-Carnitine (LC) plays an important role in the metabolism of fatty acids, and LC deficiency is
associated with a feeling of weakness or general fatigue. Cancer patients receiving …

[HTML][HTML] L-carnitine supplementation in patients with advanced cancer and carnitine deficiency: a double-blind, placebo-controlled study

RA Cruciani, E Dvorkin, P Homel, B Culliney… - Journal of pain and …, 2009 - Elsevier
Carnitine deficiency is prevalent in populations with chronic illness, including cancer. In a
recent open-label study, l-carnitine supplementation was well tolerated and appeared to …

Efficacy of l-carnitine administration on fatigue, nutritional status, oxidative stress, and related quality of life in 12 advanced cancer patients undergoing anticancer …

G Gramignano, MR Lusso, C Madeddu, E Massa… - Nutrition, 2006 - Elsevier
OBJECTIVE: Fatigue is a multidimensional symptom that is described in terms of perceived
energy, mental capacity, and psychological status: it can impair daily functioning and lead to …

[HTML][HTML] Efficacy and effectiveness of carnitine supplementation for cancer-related fatigue: a systematic literature review and meta-analysis

W Marx, L Teleni, RS Opie, J Kelly, S Marshall… - Nutrients, 2017 - mdpi.com
Background: Carnitine deficiency has been implicated as a potential pathway for cancer-
related fatigue that could be treated with carnitine supplementation. The aim of this …

Muscle carnitine in hypo‐and hyperthyroidism

C Sinclair, JM Gilchrist, JV Hennessey… - Muscle & Nerve …, 2005 - Wiley Online Library
Weakness is common in both hyper‐and hypothyroidism, and skeletal muscle l‐carnitine
may play a role in this regard, as suggested by studies indicating abnormal levels of …