Nosocomial and community-acquired infections caused by multidrug resistant bacteria
represent a major human health problem. Thus, there is an urgent need for the development …

Various reports of multidrug-resistant bacteria that are immune to all available FDA-
approved drugs demand the development of novel chemical scaffolds as antibiotics. From …

The ever increasing multidrug-resistance of clinically important pathogens and the lack of
novel antibiotics have resulted in a true antibiotic crisis where many antibiotics are no longer …

Carbapenem-resistant Enterobacterales (CRE) has emerged as a worldwide spread
nosocomial superbug exhibiting antimicrobial resistance (AMR) to all current antibiotics …

Many of the microorganisms (eg viruses, bacteria, fungi, protozoa, etc.) that exist in the
environment are able to parasitize animals and humans. When the host-parasite …

Antimicrobial resistance is a global challenge and the effectiveness of old antibiotics is
decreasing. Discovery and development of antibacterial agents have been accelerated to …

Antibiotic-resistant bacteria represent a serious threat to modern medicine and human life.
Only a minority of antibacterial agents are active against Gram-negative bacteria. Hence, the …

Infectious diseases are one of the most important and urgent health problems in the world.
According to the World Health Organization (WHO) statistics, infectious and parasitic …

Bacteria are increasingly developing resistance against the antibiotics of last resort, which
has created enormous threats in the face of global public health. In order to address this …

The ability of several N-phenyl-1H-pyrazole-4-carboxamide derivatives and other pyrazoles
opportunely modified at the positions 3, 4 and 5, to reduce the formation of the biofilm in …