Abstract Background Intact Toll-like receptor 4 (TLR4) has been identified in hepatic stellate
cells (HSCs), the primary fibrogenic cell type in liver. Here, we investigated the impact of …

Activated hepatic stellate cells (HSCs) play a key role in hepatic fibrogenesis. In injured liver
they are the main extracellular matrix protein producing cell type and further perpetuate …

Toll-like receptors (TLRs) are a family of transmembrane pattern recognition receptors
(PRR) that play a key role in innate and adaptive immunity by recognizing structural …

Bacterial lipopolysaccharide (LPS) stimulates Kupffer cells and participates in the
pathogenesis of alcohol‐induced liver injury. However, it is unknown whether LPS directly …

With their location in the perisinusoidal space of Disse, hepatic stellate cells (HSCs)
communicate with all of the liver cell types both by physical association (cell body as well as …

Toll-like Receptor 3 (TLR3) is a pathogen pattern recognition receptor that plays a key role
in innate immunity. TLR3 signalling has numerous functions in liver, both in health and …

Cholestatic liver injury may activate HSCs (hepatic stellate cells) to a profibrogenic
phenotype, contributing to liver fibrogenesis. We have previously demonstrated the …

Accumulating evidence indicates that bacteria and bacterial products promote hepatic
fibrogenesis. The activation of hepatic stellate cells (HSC) plays a central role in hepatic …

In a recent study, a single nucleotide polymorphism (SNP) of the Toll‐like receptor 4 (TLR4)
gene (c. 1196C> T [rs4986791, p. T399I]) emerged as conferring protection from fibrosis …

Toll‐like receptors (TLRs) function as key regulators of liver fibrosis and are able to
modulate the fibrogenic actions of nonparenchymal liver cells. The fibrogenic signaling …