Abstract In 2015 the United Kingdom became the first jurisdiction to approve “mitochondrial
replacement techniques”(MRT), thereby dropping prohibitions against creating human …

Abstract In 2015 the United Kingdom (UK) became the first nation to legalize egg and
zygotic nuclear transfer procedures using mitochondrial replacement techniques (MRTs) to …

Abstract The United Kingdom is the first and so far only country to pass explicit legislation
allowing for the licensed use of the new reproductive technology known as mitochondrial …

The clinical uses of cytoplasmic transfer and pronuclear transfer for infertility treatment have
raised concerns, leading to restrictive regulatory responses in both the USA and China. In …

Background Recent technological development allows nearly complete replacement of the
cytoplasm of egg/embryo, eliminating the transmission of undesired defective mitochondria …

This chapter examines the ethical and regulatory issues arising from the draft Regulation,
including the regulatory approach to the mitochondrial donor who would enable these …

MRT opponents have raised several concerns, including possible harms from the disruption
of specific mitochondrial and nuclear genome interactions, based on possible evidence from …

Background The first live birth following the use of a new reproductive technique, maternal
spindle transfer (MST), which is a mitochondrial replacement technique (MRT), was …

The UK's decision to allow mitochondrial replacement continues to stir an already active
debate. Tetsuya Ishii (2014) has analysed a number of arguments for and against this …

Preclinical experiments are currently performed to examine the feasibility of several types of
nuclear transfer to prevent mitochondrial DNA (mtDNA) disorders. Whereas the two most …