Hydrogels containing porphyrin-loaded nanoparticles for topical photodynamic applications

JA Gonzalez-Delgado, PM Castro, A Machado… - International Journal of …, 2016 - Elsevier
Abstract 5, 10, 15, 20-tetrakis (1-methylpyridinium-4-yl)-porphyrin tetra-iodide (TMPyP), a
potent water-soluble photosensitizer (PS) used in antimicrobial applications, was …

Improved In vitro and In vivo Cutaneous Delivery of Protoporphyrin IX from PLGA‐based Nanoparticles

CL Da Silva, JO Del Ciampo… - Photochemistry and …, 2013 - Wiley Online Library
We report the development of d, l lactic co‐glycolic acid)(PLGA)‐based nanoparticles (NPs)
for topical delivery of protoporphyrin IX (PpIX), a photosensitizer (PS), in treatments like …

Photosensitizer-hyaluronic acid complexes for antimicrobial photodynamic therapy (aPDT)

B Khurana, TS Ouk, R Lucas, MO Senge… - Journal of Porphyrins …, 2022 - World Scientific
The number of drug-resistant bacteria is increasing significantly. To combat such issues,
antimicrobial PDT (aPDT) provides an efficient way to eliminate these species efficiently …

PLGA nanoparticles as delivery systems for protoporphyrin IX in topical PDT: cutaneous penetration of photosensitizer observed by fluorescence microscopy

CL da Silva, JO Del Ciampo, FC Rossetti… - … of Nanoscience and …, 2013 - ingentaconnect.com
Poly (D, L lactic-co-glycolic acid)(PLGA) based nanoparticles (NPs) are proposed for topical
delivery of Protoporphyrin IX (PpIX) in Photodynamic Therapy of skin cancers. PpIX loaded …

Development and characterization of bio-derived polyhydroxyalkanoate nanoparticles as a delivery system for hydrophobic photodynamic therapy agents

S Pramual, A Assavanig, M Bergkvist, CA Batt… - Journal of Materials …, 2016 - Springer
In this study, we developed and investigated nanoparticles of biologically-derived,
biodegradable polyhydroxyalkanoates (PHAs) as carriers of a hydrophobic photosensitizer …

Encapsulation of Hydrophobic Porphyrins into Biocompatible Nanoparticles: An Easy Way to Benefit of Their Two-Photon Phototherapeutic Effect without Hydrophilic …

L Shi, C Nguyen, M Daurat, N Richy, C Gauthier… - Cancers, 2022 - mdpi.com
Simple Summary Efficient photosensitizers for photodyanmic therapy (PDT) need to be
soluble in physiologic media. This requirement often complicates significantly the chemical …

Novel nanostructural photosensitizers for photodynamic therapy: in vitro studies

K Nawalany, A Rusin, M Kepczynski, P Filipczak… - International journal of …, 2012 - Elsevier
Photosensitizing properties of 5, 10, 15, 20-tetrakis (4-hydroxyphenyl) porphyrin (p-THPP)
functionalized by covalent attachment of one chain of poly (ethylene glycol)(PEG) with a …

In vivo photodynamic activity of photosensitizer-loaded nanoparticles: formulation properties, administration parameters and biological issues involved in PDT …

A Vargas, M Eid, M Fanchaouy, R Gurny… - European journal of …, 2008 - Elsevier
Encapsulation of hydrophobic photosensitizers (PS) into polymeric nanoparticles (NP) has
proven to be an effective alternative to organic solvents for their formulation. As NP size …

Enhanced fluorescence emission and singlet oxygen generation of photosensitizers embedded in injectable hydrogels for imaging-guided photodynamic cancer …

LY Xia, X Zhang, M Cao, Z Chen, FG Wu - Biomacromolecules, 2017 - ACS Publications
Benefiting from their inherent localized and controlled release properties, hydrogels are
ideal delivery systems for therapeutic drugs or nanoparticles. In particular, applications of …

Enhanced photodynamic activity of meso-tetra (4-hydroxyphenyl) porphyrin by incorporation into sub-200 nm nanoparticles

YN Konan, M Berton, R Gurny, E Allémann - European journal of …, 2003 - Elsevier
A photosensitizer, meso-tetra (hydroxyphenyl) porphyrin (p-THPP) was incorporated into
sterile submicronic nanoparticles of poly (d, l-lactide-co-glycolide)(50: 50 and 75: 25 PLGA) …