[HTML][HTML] Molecular and clinical significance of fibroblast growth factor 2 (FGF2/bFGF) in malignancies of solid and hematological cancers for personalized therapies

MR Akl, P Nagpal, NM Ayoub, B Tai, SA Prabhu… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Fibroblast growth factor (FGF) signaling is essential for normal and cancer biology.
Mammalian FGF family members participate in multiple signaling pathways by binding to …

The role of fibroblast growth factors in tumor growth

M Korc, RE Friesel - Current cancer drug targets, 2009 - ingentaconnect.com
Biological processes that drive cell growth are exciting targets for cancer therapy. The
fibroblast growth factor (FGF) signaling network plays a ubiquitous role in normal cell …

Therapeutics targeting FGF signaling network in human diseases

M Katoh - Trends in pharmacological sciences, 2016 - cell.com
Fibroblast growth factor (FGF) signaling through its receptors, FGFR1, FGFR2, FGFR3, or
FGFR4, regulates cell fate, angiogenesis, immunity, and metabolism. Dysregulated FGF …

Fibroblast growth factors and their receptors in cancer

J Wesche, K Haglund, EM Haugsten - Biochemical Journal, 2011 - portlandpress.com
FGFs (fibroblast growth factors) and their receptors (FGFRs) play essential roles in tightly
regulating cell proliferation, survival, migration and differentiation during development and …

De-regulated FGF receptors as therapeutic targets in cancer

V Knights, SJ Cook - Pharmacology & therapeutics, 2010 - Elsevier
Fibroblast growth factors (FGFs) acting through their cognate receptors (FGFRs) play vital
roles in development and de-regulation of FGF/FGFR signalling is associated with many …

Fibroblast growth factor signalling: from development to cancer

N Turner, R Grose - Nature Reviews Cancer, 2010 - nature.com
Fibroblast growth factors (FGFs) and their receptors control a wide range of biological
functions, regulating cellular proliferation, survival, migration and differentiation. Although …

Dysregulated FGF signalling in neoplastic disorders

Y Tanner, RP Grose - Seminars in cell & developmental biology, 2016 - Elsevier
The fibroblast growth factor (FGF) signalling pathway contributes to the regulation of a
multitude of cellular functions, impacting on proliferation, survival, differentiation and …

Targeting fibroblast-growth-factor-receptor-dependent signaling for cancer therapy

C Heinzle, H Sutterlüty, M Grusch… - Expert opinion on …, 2011 - Taylor & Francis
Introduction: Fibroblast growth factors (FGF) exert a combination of biological effects that
contribute to four of the six essential hallmarks of cancer. It is no surprise that FGF …

Molecular pathways: fibroblast growth factor signaling: a new therapeutic opportunity in cancer

AN Brooks, E Kilgour, PD Smith - Clinical cancer research, 2012 - AACR
The fibroblast growth factor/fibroblast growth factor receptor (FGF/FGFR) signaling axis plays
an important role in normal organ, vascular, and skeletal development. Deregulation of …

FGF/FGFR-dependent molecular mechanisms underlying anti-cancer drug resistance

J Szymczyk, KD Sluzalska, I Materla, L Opalinski… - Cancers, 2021 - mdpi.com
Simple Summary Deregulation of the FGF/FGFR axis is associated with many types of
cancer and contributes to the development of chemoresistance, limiting the effectiveness of …