[HTML][HTML] Molecular and clinical significance of fibroblast growth factor 2 (FGF2/bFGF) in malignancies of solid and hematological cancers for personalized therapies
Fibroblast growth factor (FGF) signaling is essential for normal and cancer biology.
Mammalian FGF family members participate in multiple signaling pathways by binding to …
Mammalian FGF family members participate in multiple signaling pathways by binding to …
The role of fibroblast growth factors in tumor growth
M Korc, RE Friesel - Current cancer drug targets, 2009 - ingentaconnect.com
Biological processes that drive cell growth are exciting targets for cancer therapy. The
fibroblast growth factor (FGF) signaling network plays a ubiquitous role in normal cell …
fibroblast growth factor (FGF) signaling network plays a ubiquitous role in normal cell …
Therapeutics targeting FGF signaling network in human diseases
M Katoh - Trends in pharmacological sciences, 2016 - cell.com
Fibroblast growth factor (FGF) signaling through its receptors, FGFR1, FGFR2, FGFR3, or
FGFR4, regulates cell fate, angiogenesis, immunity, and metabolism. Dysregulated FGF …
FGFR4, regulates cell fate, angiogenesis, immunity, and metabolism. Dysregulated FGF …
Fibroblast growth factors and their receptors in cancer
J Wesche, K Haglund, EM Haugsten - Biochemical Journal, 2011 - portlandpress.com
FGFs (fibroblast growth factors) and their receptors (FGFRs) play essential roles in tightly
regulating cell proliferation, survival, migration and differentiation during development and …
regulating cell proliferation, survival, migration and differentiation during development and …
De-regulated FGF receptors as therapeutic targets in cancer
V Knights, SJ Cook - Pharmacology & therapeutics, 2010 - Elsevier
Fibroblast growth factors (FGFs) acting through their cognate receptors (FGFRs) play vital
roles in development and de-regulation of FGF/FGFR signalling is associated with many …
roles in development and de-regulation of FGF/FGFR signalling is associated with many …
Fibroblast growth factor signalling: from development to cancer
N Turner, R Grose - Nature Reviews Cancer, 2010 - nature.com
Fibroblast growth factors (FGFs) and their receptors control a wide range of biological
functions, regulating cellular proliferation, survival, migration and differentiation. Although …
functions, regulating cellular proliferation, survival, migration and differentiation. Although …
Dysregulated FGF signalling in neoplastic disorders
Y Tanner, RP Grose - Seminars in cell & developmental biology, 2016 - Elsevier
The fibroblast growth factor (FGF) signalling pathway contributes to the regulation of a
multitude of cellular functions, impacting on proliferation, survival, differentiation and …
multitude of cellular functions, impacting on proliferation, survival, differentiation and …
Targeting fibroblast-growth-factor-receptor-dependent signaling for cancer therapy
C Heinzle, H Sutterlüty, M Grusch… - Expert opinion on …, 2011 - Taylor & Francis
Introduction: Fibroblast growth factors (FGF) exert a combination of biological effects that
contribute to four of the six essential hallmarks of cancer. It is no surprise that FGF …
contribute to four of the six essential hallmarks of cancer. It is no surprise that FGF …
Molecular pathways: fibroblast growth factor signaling: a new therapeutic opportunity in cancer
AN Brooks, E Kilgour, PD Smith - Clinical cancer research, 2012 - AACR
The fibroblast growth factor/fibroblast growth factor receptor (FGF/FGFR) signaling axis plays
an important role in normal organ, vascular, and skeletal development. Deregulation of …
an important role in normal organ, vascular, and skeletal development. Deregulation of …
FGF/FGFR-dependent molecular mechanisms underlying anti-cancer drug resistance
J Szymczyk, KD Sluzalska, I Materla, L Opalinski… - Cancers, 2021 - mdpi.com
Simple Summary Deregulation of the FGF/FGFR axis is associated with many types of
cancer and contributes to the development of chemoresistance, limiting the effectiveness of …
cancer and contributes to the development of chemoresistance, limiting the effectiveness of …