Targets and patented drugs for chemotherapy of Chagas disease in the last 15 years-period

VG Duschak - Recent patents on anti-infective drug discovery, 2016 - ingentaconnect.com
Background: The American trypanosomiasis, Chagas disease, is a parasitic infection
typically spread by triatomine vectors affecting millions of people all over Latin America …

A decade of targets and patented drugs for chemotherapy of Chagas disease

VG Duschak - Recent patents on anti-infective drug discovery, 2011 - ingentaconnect.com
Chagas disease, a parasitic infection typically spread by triatomine bugs, affects millions of
people throughout Latin America. Current chemotherapy based on the nitroaromatic …

Specific chemotherapy of Chagas disease: controversies and advances

JA Urbina, R Docampo - Trends in parasitology, 2003 - cell.com
Chagas disease, caused by Trypanosoma cruzi, is a major public health problem in Latin
America, where it constitutes one of the largest parasitic disease burdens. Specific treatment …

Advances in Chagas disease chemotherapy

PMM Guedes, JLR Fietto, M Lana… - Anti-Infective Agents in …, 2006 - ingentaconnect.com
Chagas disease is endemic from Mexico to Argentina, where it is estimated that 16 to 18
million people are infected with its causative agent, Trypanosoma cruzi, and 100 million …

An insight on targets and patented drugs for chemotherapy of Chagas disease

VG Duschak, AS Couto - Recent patents on anti-infective drug …, 2007 - ingentaconnect.com
Chagas disease or American Trypanosomiasis, a parasitic infection typically spread by
triatomine bugs, affects millions of people throughout Latin America. Current chemotherapy …

New chemotherapeutic approaches for the treatment of Chagas disease (American Trypanosomiasis)

JA Urbina - Expert Opinion on Therapeutic Patents, 2003 - Taylor & Francis
Chagas disease is one of the most serious public health problems in Latin America but, due
to economic considerations, there is almost no research and development effort by the …

Review on Experimental Treatment Strategies Against Trypanosoma cruzi

AL Mazzeti, P Capelari-Oliveira, MT Bahia… - Journal of …, 2021 - Taylor & Francis
Chagas disease is a neglected tropical disease caused by the protozoan Trypanosoma
cruzi. Currently, only nitroheterocyclic nifurtimox (NFX) and benznidazole (BNZ) are …

Challenges in Chagas disease drug discovery: a review

R Paucar, E Moreno-Viguri… - Current Medicinal …, 2016 - ingentaconnect.com
Chagas disease or American trypanosomiasis is a neglected tropical disease caused by the
parasite Trypanosoma cruzi. Although the number of infected individuals has decreased …

Chagas disease: progress and new perspectives

F Sanchez-Sancho, NE Campillo… - Current Medicinal …, 2010 - ingentaconnect.com
Chagas disease, also known as American trypanosomiasis, is caused by infection with the
protozoan parasite Trypanosoma cruzi. The Pan American Health Organization (PAHO) …

Nitroheterocyclic compounds are more efficacious than CYP51 inhibitors against Trypanosoma cruzi: implications for Chagas disease drug discovery and …

CB Moraes, MA Giardini, H Kim, CH Franco… - Scientific reports, 2014 - nature.com
Advocacy for better drugs and access to treatment has boosted the interest in drug discovery
and development for Chagas disease, a chronic infection caused by the genetically …