Circadian time signatures of fitness and disease

J Bass, MA Lazar - Science, 2016 - science.org
Biological clocks are autonomous anticipatory oscillators that play a critical role in the
organization and information processing from genome to whole organisms. Transformative …

Communicating clocks shape circadian homeostasis

KB Koronowski, P Sassone-Corsi - Science, 2021 - science.org
BACKGROUND Life-forms ranging from bacteria to humans are programmed by circadian
clocks—mechanisms that impose an~ 24-hour rhythmicity on biology in harmony with …

Molecular architecture of the mammalian circadian clock

CL Partch, CB Green, JS Takahashi - Trends in cell biology, 2014 - cell.com
Circadian clocks coordinate physiology and behavior with the 24h solar day to provide
temporal homeostasis with the external environment. The molecular clocks that drive these …

Circadian clocks—the fall and rise of physiology

T Roenneberg, M Merrow - Nature Reviews Molecular Cell Biology, 2005 - nature.com
Circadian clocks control the daily life of most light-sensitive organisms—from cyanobacteria
to humans. Molecular processes generate cellular rhythmicity, and cellular clocks in animals …

The circadian coordination of cell biology

A Chaix, A Zarrinpar, S Panda - Journal of Cell Biology, 2016 - rupress.org
Circadian clocks are cell-autonomous timing mechanisms that organize cell functions in a
24-h periodicity. In mammals, the main circadian oscillator consists of transcription …

Transcriptional control of circadian rhythms and metabolism: a matter of time and space

YH Kim, MA Lazar - Endocrine Reviews, 2020 - academic.oup.com
All biological processes, living organisms, and ecosystems have evolved with the Sun that
confers a 24-hour periodicity to life on Earth. Circadian rhythms arose from evolutionary …

Clocks not winding down: unravelling circadian networks

EE Zhang, SA Kay - Nature reviews Molecular cell biology, 2010 - nature.com
An intrinsic clock enables an organism to anticipate environmental changes and use energy
sources more efficiently, thereby conferring an adaptive advantage. Having an intrinsic clock …

Circadian topology of metabolism

J Bass - Nature, 2012 - nature.com
Biological clocks are genetically encoded oscillators that allow organisms to anticipate
changes in the light–dark environment that are tied to the rotation of Earth. Clocks enhance …

[HTML][HTML] The daily rhythms of genes, cells and organs: biological clocks and circadian timing in cells

U Schibler - EMBO reports, 2005 - embopress.org
All living organisms have time-measuring devices that affect their development, generation
time, lifespan and lifestyle. These biological timers can be categorized into hourglasses and …

The role of the circadian clock system in physiology

V Pilorz, C Helfrich-Förster, H Oster - Pflügers Archiv-European Journal of …, 2018 - Springer
Life on earth is shaped by the 24-h rotation of our planet around its axes. To adapt behavior
and physiology to the concurring profound but highly predictable changes, endogenous …