Corticothalamic projection neurons (CThPN) are a diverse set of neurons, critical for function
of the neocortex. CThPN development and diversity need to be precisely regulated, but little …

Neural basic helix-loop-helix (bHLH) transcription factors are crucial in regulating the
differentiation and neuronal subtype specification of neurons. Precisely how these …

Identities of distinct neuron subtypes are specified during embryonic development, then
maintained during post-natal maturation. In cerebral cortex, mechanisms controlling early …

Generating a balanced network of inhibitory and excitatory neurons during development
requires precise transcriptional control. In the dorsal spinal cord, Ptf1a, a basic helix-loop …

The mammalian neocortex is a highly organized six-layered structure with four major cortical
neuron subtypes: corticothalamic projection neurons (CThPNs), subcerebral projection …

The cerebral cortex contains billions of neurons, and their disorganization or
misspecification leads to neurodevelopmental disorders. Understanding how the plethora of …

Neurogliaform (RELN+) and bipolar (VIP+) GABAergic interneurons of the mammalian
cerebral cortex provide critical inhibition locally within the superficial layers. While these …

The molecular mechanisms regulating fate divergence of closely related, but distinct, layer 6
corticothalamic and layer 5 subcerebral projection neurons are largely unknown. We …

The neocortex contains an unparalleled diversity of neuronal subtypes, each defined by
distinct traits that are developmentally acquired under the control of subtype-specific and …

The mechanisms that activate some genes while silencing others are critical to ensure
precision in lineage specification as multipotent progenitors become restricted in cell fate …