Corticothalamic projection neuron development beyond subtype specification: Fog2 and intersectional controls regulate intraclass neuronal diversity
MJ Galazo, JG Emsley, JD Macklis - Neuron, 2016 - cell.com
Corticothalamic projection neurons (CThPN) are a diverse set of neurons, critical for function
of the neocortex. CThPN development and diversity need to be precisely regulated, but little …
of the neocortex. CThPN development and diversity need to be precisely regulated, but little …
In vivo neuronal subtype-specific targets of Atoh1 (Math1) in dorsal spinal cord
Neural basic helix-loop-helix (bHLH) transcription factors are crucial in regulating the
differentiation and neuronal subtype specification of neurons. Precisely how these …
differentiation and neuronal subtype specification of neurons. Precisely how these …
[HTML][HTML] Tle4 controls both developmental acquisition and early post-natal maturation of corticothalamic projection neuron identity
Identities of distinct neuron subtypes are specified during embryonic development, then
maintained during post-natal maturation. In cerebral cortex, mechanisms controlling early …
maintained during post-natal maturation. In cerebral cortex, mechanisms controlling early …
[HTML][HTML] Prdm13 mediates the balance of inhibitory and excitatory neurons in somatosensory circuits
JC Chang, DM Meredith, PR Mayer, MD Borromeo… - Developmental cell, 2013 - cell.com
Generating a balanced network of inhibitory and excitatory neurons during development
requires precise transcriptional control. In the dorsal spinal cord, Ptf1a, a basic helix-loop …
requires precise transcriptional control. In the dorsal spinal cord, Ptf1a, a basic helix-loop …
FOXG1 sequentially orchestrates subtype specification of postmitotic cortical projection neurons
J Liu, M Yang, M Su, B Liu, K Zhou, C Sun, R Ba… - Science …, 2022 - science.org
The mammalian neocortex is a highly organized six-layered structure with four major cortical
neuron subtypes: corticothalamic projection neurons (CThPNs), subcerebral projection …
neuron subtypes: corticothalamic projection neurons (CThPNs), subcerebral projection …
Temporal and sequential transcriptional dynamics define lineage shifts in corticogenesis
The cerebral cortex contains billions of neurons, and their disorganization or
misspecification leads to neurodevelopmental disorders. Understanding how the plethora of …
misspecification leads to neurodevelopmental disorders. Understanding how the plethora of …
Prox1 regulates the subtype-specific development of caudal ganglionic eminence-derived GABAergic cortical interneurons
G Miyoshi, A Young, T Petros, T Karayannis… - Journal of …, 2015 - Soc Neuroscience
Neurogliaform (RELN+) and bipolar (VIP+) GABAergic interneurons of the mammalian
cerebral cortex provide critical inhibition locally within the superficial layers. While these …
cerebral cortex provide critical inhibition locally within the superficial layers. While these …
Tbr1 and Fezf2 regulate alternate corticofugal neuronal identities during neocortical development
WL McKenna, J Betancourt, KA Larkin… - Journal of …, 2011 - Soc Neuroscience
The molecular mechanisms regulating fate divergence of closely related, but distinct, layer 6
corticothalamic and layer 5 subcerebral projection neurons are largely unknown. We …
corticothalamic and layer 5 subcerebral projection neurons are largely unknown. We …
Gene co-regulation by Fezf2 selects neurotransmitter identity and connectivity of corticospinal neurons
The neocortex contains an unparalleled diversity of neuronal subtypes, each defined by
distinct traits that are developmentally acquired under the control of subtype-specific and …
distinct traits that are developmentally acquired under the control of subtype-specific and …
Repression by PRDM13 is critical for generating precision in neuronal identity
The mechanisms that activate some genes while silencing others are critical to ensure
precision in lineage specification as multipotent progenitors become restricted in cell fate …
precision in lineage specification as multipotent progenitors become restricted in cell fate …