Sleep-active neuron specification and sleep induction require FLP-11 neuropeptides to systemically induce sleep
M Turek, J Besseling, JP Spies, S König, H Bringmann - Elife, 2016 - elifesciences.org
Sleep is an essential behavioral state. It is induced by conserved sleep-active neurons that
express GABA. However, little is known about how sleep neuron function is determined and …
express GABA. However, little is known about how sleep neuron function is determined and …
[PDF][PDF] Epidermal growth factor signaling promotes sleep through a combined series and parallel neural circuit
Sleep requires sleep-active neurons that depolarize to inhibit wake circuits. Sleep-active
neurons are under the control of homeostatic mechanisms that determine sleep need …
neurons are under the control of homeostatic mechanisms that determine sleep need …
[PDF][PDF] An AP2 transcription factor is required for a sleep-active neuron to induce sleep-like quiescence in C. elegans
M Turek, I Lewandrowski, H Bringmann - Current Biology, 2013 - cell.com
Background Sleep is an essential behavior that is found in all animals that have a nervous
system. Neural activity is thought to control sleep, but little is known about the identity and …
system. Neural activity is thought to control sleep, but little is known about the identity and …
[PDF][PDF] C. elegans stress-induced sleep emerges from the collective action of multiple neuropeptides
The genetic basis of sleep regulation remains poorly understood. In C. elegans, cellular
stress induces sleep through epidermal growth factor (EGF)-dependent activation of the EGF …
stress induces sleep through epidermal growth factor (EGF)-dependent activation of the EGF …
Conservation of sleep: insights from non-mammalian model systems
JE Zimmerman, N Naidoo, DM Raizen, AI Pack - Trends in neurosciences, 2008 - cell.com
The past 10 years have seen new approaches to elucidating genetic pathways regulating
sleep. The emerging theme is that sleep-like states are conserved in evolution, with similar …
sleep. The emerging theme is that sleep-like states are conserved in evolution, with similar …
The RFamide receptor DMSR-1 regulates stress-induced sleep in C. elegans
MJ Iannacone, I Beets, LE Lopes, MA Churgin… - elife, 2017 - elifesciences.org
In response to environments that cause cellular stress, animals engage in sleep behavior
that facilitates recovery from the stress. In Caenorhabditis elegans, stress-induced sleep …
that facilitates recovery from the stress. In Caenorhabditis elegans, stress-induced sleep …
[HTML][HTML] Tfap2b acts in GABAergic neurons to control sleep in mice
Y Hu, H Bringmann - Scientific Reports, 2023 - nature.com
Sleep is a universal state of behavioral quiescence in both vertebrates and invertebrates
that is controlled by conserved genes. We previously found that AP2 transcription factors …
that is controlled by conserved genes. We previously found that AP2 transcription factors …
[HTML][HTML] A GABAergic and peptidergic sleep neuron as a locomotion stop neuron with compartmentalized Ca2+ dynamics
W Steuer Costa, P Van der Auwera, C Glock… - Nature …, 2019 - nature.com
Animals must slow or halt locomotion to integrate sensory inputs or to change direction. In
Caenorhabditis elegans, the GABAergic and peptidergic neuron RIS mediates …
Caenorhabditis elegans, the GABAergic and peptidergic neuron RIS mediates …
Sleep-active neurons: conserved motors of sleep
H Bringmann - Genetics, 2018 - academic.oup.com
Sleep is crucial for survival and well-being. This behavioral and physiological state has
been studied in all major genetically accessible model animals, including rodents, fish, flies …
been studied in all major genetically accessible model animals, including rodents, fish, flies …
[PDF][PDF] Sleep drive is encoded by neural plastic changes in a dedicated circuit
Prolonged wakefulness leads to an increased pressure for sleep, but how this homeostatic
drive is generated and subsequently persists is unclear. Here, from a neural circuit screen in …
drive is generated and subsequently persists is unclear. Here, from a neural circuit screen in …