The skeleton is an exquisitely sensitive and archetypal T3-target tissue that demonstrates
the critical role for thyroid hormones during development, linear growth, and adult bone …

BACKGROUND: Thyroid hormones regulate skeletal development, acquisition of peak bone
mass and adult bone maintenance. Abnormal thyroid status during childhood disrupts bone …

The hypothalamic–pituitary–thyroid axis plays a key role in skeletal development,
acquisition of peak bone mass and regulation of adult bone turnover. Euthyroid status is …

Thyroid hormones exert widespread and complex actions in almost all tissues during
development, throughout childhood and in adults. The skeleton is an important T3-target …

Thyroid hormone (T 3) is essential for the normal development of endochondral and
intramembranous bone and plays an important role in the linear growth and maintenance of …

The importance of the thyroid hormone axis in the regulation of skeletal growth and
maintenance has been well established from clinical studies involving patients with …

Studies in genetically modified mice have highlighted the importance of the hypothalamic–
pituitary–thyroid (HPT) axis during skeletal development and the maintenance of adult bone …

Linear growth and skeletal maturation occur during fetal and childhood development and
continue until epiphyseal fusion occurs. This process results from endochondral ossification …

Thyroid hormone (T3) regulates bone turnover and mineralization in adults and is essential
for skeletal development. Surprisingly, we identified a phenotype of skeletal thyrotoxicosis in …

Thyroid hormones are required for skeletal development and establishment of peak bone
mass. Hypothyroidism in children results in growth retardation with delayed skeletal …