Components and mechanisms of import, modification, folding, and assembly of immunoglobulins in the endoplasmic reticulum

R Zimmermann - Journal of Clinical Immunology, 2016 - Springer
In mammalian cells, the endoplasmic reticulum (ER) plays a central role in biogenesis of
secretory-and plasma membrane proteins as well as in cellular calcium (Ca 2+) …

[HTML][HTML] Complexity and specificity of Sec61-channelopathies: human diseases affecting gating of the Sec61 complex

M Sicking, S Lang, F Bochen, A Roos, JPH Drenth… - Cells, 2021 - mdpi.com
The rough endoplasmic reticulum (ER) of nucleated human cells has crucial functions in
protein biogenesis, calcium (Ca2+) homeostasis, and signal transduction. Among the …

Protein transport into the human ER and related diseases, Sec61-channelopathies

S Haßdenteufel, MC Klein, A Melnyk… - … and Cell Biology, 2014 - cdnsciencepub.com
Protein transport into the human endoplasmic reticulum (ER) is relevant to the biogenesis of
most soluble and membrane proteins of organelles, which are involved in endo-or exo …

[HTML][HTML] Co-chaperone specificity in gating of the polypeptide conducting channel in the membrane of the human endoplasmic reticulum

S Schorr, MC Klein, I Gamayun, A Melnyk… - Journal of Biological …, 2015 - ASBMB
In mammalian cells, signal peptide-dependent protein transport into the endoplasmic
reticulum (ER) is mediated by a dynamic polypeptide-conducting channel, the heterotrimeric …

Protein transport into the human endoplasmic reticulum

J Dudek, S Pfeffer, PH Lee, M Jung, A Cavalié… - Journal of molecular …, 2015 - Elsevier
Protein transport into the endoplasmic reticulum (ER) is essential for all eukaryotic cells and
evolutionary related to protein transport into and across the cytoplasmic membrane of …

[HTML][HTML] An update on Sec61 channel functions, mechanisms, and related diseases

S Lang, S Pfeffer, PH Lee, A Cavalié, V Helms… - Frontiers in …, 2017 - frontiersin.org
The membrane of the endoplasmic reticulum (ER) of nucleated human cells harbors the
protein translocon, which facilitates membrane integration or translocation of almost every …

[HTML][HTML] The conserved C-terminus of Sss1p is required to maintain the endoplasmic reticulum permeability barrier

CM Witham, HG Dassanayake, AL Paxman… - Journal of Biological …, 2020 - ASBMB
The endoplasmic reticulum (ER) is the entry point to the secretory pathway and major site of
protein biogenesis. Translocation of secretory and integral membrane proteins across or into …

BiP‐mediated closing of the Sec61 channel limits Ca2+ leakage from the ER

N Schäuble, S Lang, M Jung, S Cappel, S Schorr… - The EMBO …, 2012 - embopress.org
In mammalian cells, signal peptide‐dependent protein transport into the endoplasmic
reticulum (ER) is mediated by a dynamic protein‐conducting channel, the Sec61 complex …

[HTML][HTML] Antigen presentation: peptides and proteins scramble for the exit

PJ Lehner, EW Hewitt, K Römisch - Current Biology, 2000 - cell.com
The fate of peptides that fail to bind to major histocompatibility complex class I molecules in
the endoplasmic reticulum (ER) has remained unclear. A recent study has revealed that …

[HTML][HTML] Protein translocation across the ER membrane

R Zimmermann, S Eyrisch, M Ahmad… - Biochimica et Biophysica …, 2011 - Elsevier
Protein translocation into the endoplasmic reticulum (ER) is the first and decisive step in the
biogenesis of most extracellular and many soluble organelle proteins in eukaryotic cells. It is …