Components and mechanisms of import, modification, folding, and assembly of immunoglobulins in the endoplasmic reticulum
R Zimmermann - Journal of Clinical Immunology, 2016 - Springer
In mammalian cells, the endoplasmic reticulum (ER) plays a central role in biogenesis of
secretory-and plasma membrane proteins as well as in cellular calcium (Ca 2+) …
secretory-and plasma membrane proteins as well as in cellular calcium (Ca 2+) …
[HTML][HTML] Complexity and specificity of Sec61-channelopathies: human diseases affecting gating of the Sec61 complex
M Sicking, S Lang, F Bochen, A Roos, JPH Drenth… - Cells, 2021 - mdpi.com
The rough endoplasmic reticulum (ER) of nucleated human cells has crucial functions in
protein biogenesis, calcium (Ca2+) homeostasis, and signal transduction. Among the …
protein biogenesis, calcium (Ca2+) homeostasis, and signal transduction. Among the …
Protein transport into the human ER and related diseases, Sec61-channelopathies
S Haßdenteufel, MC Klein, A Melnyk… - … and Cell Biology, 2014 - cdnsciencepub.com
Protein transport into the human endoplasmic reticulum (ER) is relevant to the biogenesis of
most soluble and membrane proteins of organelles, which are involved in endo-or exo …
most soluble and membrane proteins of organelles, which are involved in endo-or exo …
[HTML][HTML] Co-chaperone specificity in gating of the polypeptide conducting channel in the membrane of the human endoplasmic reticulum
S Schorr, MC Klein, I Gamayun, A Melnyk… - Journal of Biological …, 2015 - ASBMB
In mammalian cells, signal peptide-dependent protein transport into the endoplasmic
reticulum (ER) is mediated by a dynamic polypeptide-conducting channel, the heterotrimeric …
reticulum (ER) is mediated by a dynamic polypeptide-conducting channel, the heterotrimeric …
Protein transport into the human endoplasmic reticulum
Protein transport into the endoplasmic reticulum (ER) is essential for all eukaryotic cells and
evolutionary related to protein transport into and across the cytoplasmic membrane of …
evolutionary related to protein transport into and across the cytoplasmic membrane of …
[HTML][HTML] An update on Sec61 channel functions, mechanisms, and related diseases
The membrane of the endoplasmic reticulum (ER) of nucleated human cells harbors the
protein translocon, which facilitates membrane integration or translocation of almost every …
protein translocon, which facilitates membrane integration or translocation of almost every …
[HTML][HTML] The conserved C-terminus of Sss1p is required to maintain the endoplasmic reticulum permeability barrier
CM Witham, HG Dassanayake, AL Paxman… - Journal of Biological …, 2020 - ASBMB
The endoplasmic reticulum (ER) is the entry point to the secretory pathway and major site of
protein biogenesis. Translocation of secretory and integral membrane proteins across or into …
protein biogenesis. Translocation of secretory and integral membrane proteins across or into …
BiP‐mediated closing of the Sec61 channel limits Ca2+ leakage from the ER
In mammalian cells, signal peptide‐dependent protein transport into the endoplasmic
reticulum (ER) is mediated by a dynamic protein‐conducting channel, the Sec61 complex …
reticulum (ER) is mediated by a dynamic protein‐conducting channel, the Sec61 complex …
[HTML][HTML] Antigen presentation: peptides and proteins scramble for the exit
PJ Lehner, EW Hewitt, K Römisch - Current Biology, 2000 - cell.com
The fate of peptides that fail to bind to major histocompatibility complex class I molecules in
the endoplasmic reticulum (ER) has remained unclear. A recent study has revealed that …
the endoplasmic reticulum (ER) has remained unclear. A recent study has revealed that …
[HTML][HTML] Protein translocation across the ER membrane
R Zimmermann, S Eyrisch, M Ahmad… - Biochimica et Biophysica …, 2011 - Elsevier
Protein translocation into the endoplasmic reticulum (ER) is the first and decisive step in the
biogenesis of most extracellular and many soluble organelle proteins in eukaryotic cells. It is …
biogenesis of most extracellular and many soluble organelle proteins in eukaryotic cells. It is …