Background Signal transducers and activators of transcription (STAT) proteins are critical
transcription factor that are aberrantly activated in various types of malignancies, including …

Resveratrol is a naturally occurring phytoalexin with antioxidant and antiinflammatory
properties. Recent studies suggest that resveratrol possesses anticancer effects, although its …

The intracytoplasmic tyrosine kinase Src serves both as a conduit and a regulator for
multiple processes required for the proliferation and survival cancer cells. In some cancers …

STAT3, but not ERKs, mediates the IL-6–induced proliferation of renal cancer cells, ACHN
and 769P. Background Although interleukin-6 (IL-6) has been suggested to function as an …

Persistent activation of signal transducer and activator of transcription 3 (STAT3) is one of
the characteristic features of renal cell carcinoma (RCC) and often linked to its deregulated …

The signal transducer and activator of transcription 3 (STAT3) is a transcription factor mainly
activated by phosphorylation in either tyrosine 705 (Y705) or serine 727 (S727) residues …

Constitutive activation of STAT3 is frequently observed and closely linked with proliferation,
survival, invasion, metastasis and angiogenesis in tumor cells. In the present study, we …

Signal transducer and activator of transcription-3 (STAT3) is critical for cancer progression
by regulating tumor cell survival, proliferation, and angiogenesis. Herein, we investigated …

It has been established that signal transducer and activator of transcription 3 serves as an
oncoprotein in various human cancers; targeting it is therefore a reasonable approach for …

Background Hepatocellular carcinoma (HCC) is the most common primary liver malignancy.
Phloretin (PH) possesses anticancer, antitumor, and hepatoprotective effects, however, the …