Deregulated protein and Ca2+ homeostasis underlie synaptic dysfunction and
neurodegeneration in Huntington disease (HD); however, the factors that disrupt …

The transcriptional repressor DREAM (downstream regulatory element antagonist
modulator) is a multifunctional neuronal calcium sensor (NCS) that controls Ca 2+ and …

DREAM, a neuronal calcium sensor protein, has multiple cellular roles including the
regulation of Ca2+ and protein homeostasis. We recently showed that reduced DREAM …

Abstract Activating transcription factor-5 (ATF5) is a stress-response transcription factor
induced upon different cell stressors like fasting, amino-acid limitation, cadmium or arsenite …

Neuronal cell death in neurodegenerative diseases is not fully understood. Here we report
that mutant huntingtin (Htt), a causative gene product of Huntington's diseases (HD) …

Huntington's disease is a fatal neurodegenerative disorder caused by an expanded
polyglutamine repeat in huntingtin (HTT) protein. We previously showed that calorie …

The ultimate goal for Huntington's disease (HD) therapeutics is to develop disease-
modifying neuroprotective therapies that can delay or prevent illness in those who are at …

Background Huntington's disease is a progressive autosomal dominant neurodegenerative
disorder that is caused by a CAG repeat expansion in the HD or Huntington's disease gene …

Golgi stress response is emerging as a physiologic process of comparable importance to
endoplasmic reticulum (ER) and mitochondrial stress responses. However, unlike ER stress …

Background Huntington's disease (HD) is a fatal progressive neurodegenerative disorder
caused by the expansion of the polyglutamine repeat region in the huntingtin gene …