Oxidative stress and endocytosis are involved in upregulation of interleukin‐8 expression in airway cells exposed to PM 2.5

Z Yan, J Wang, J Li, N Jiang, R Zhang… - Environmental …, 2016 - Wiley Online Library
ABSTRACT Inhaled PM2. 5 (particulate matter with an aerodynamic diameter of 2.5 μm or
less) can induce lung inflammation through released inflammatory mediators from airway …

PM10-exposed macrophages stimulate a proinflammatory response in lung epithelial cells via TNF-α

LA Jimenez, EM Drost, PS Gilmour… - … of Physiology-Lung …, 2002 - journals.physiology.org
There is now considerable evidence for an association between the levels of particulate air
pollution [particulate matter< 10 μm in aerodynamic diameter (PM10)] and various adverse …

Epidermal growth factor receptor (EGFR)—MAPK—nuclear factor (NF)‐κB—IL8: A possible mechanism of particulate matter (PM) 2.5‐induced lung toxicity

SC Jeong, Y Cho, MK Song, E Lee… - Environmental …, 2017 - Wiley Online Library
Airway inflammation plays a central role in the pathophysiology of diverse pulmonary
diseases. In this study, we investigated whether exposure to particulate matter (PM) 2.5, a …

Interleukins 6/8 and cyclooxygenase‐2 release and expressions are regulated by oxidative stress‐JAK2/STAT3 signaling pathway in human bronchial epithelial cells …

Z Xu, H Wu, H Zhang, J Bai… - Journal of Applied …, 2020 - Wiley Online Library
Atmospheric particulate matter with a diameter≤ 2.5 μm (PM2. 5) can induce inflammation
of the respiratory system, which is the pathological basis of asthma or other respiratory …

PM2.5 Exposure Induces Inflammatory Response in Macrophages via the TLR4/COX-2/NF-κB Pathway

H Fu, X Liu, W Li, Y Zu, F Zhou, Q Shou, Z Ding - Inflammation, 2020 - Springer
Fine particulate matter with an aerodynamic diameter less than 2.5 μm (PM2. 5) is a serious
air pollutant associated with health problems. Macrophages play an important role in the …

PM2. 5‐induced lung inflammation in mice: Differences of inflammatory response in macrophages and type II alveolar cells

M He, T Ichinose, S Yoshida, T Ito, C He… - Journal of Applied …, 2017 - Wiley Online Library
Abstract Particulate matter 2.5 (< PM2. 5 μm) leads to chronic obstructive pulmonary
disease. In this study, biomarkers related to inflammation and oxidative stress in vitro and in …

Exposure to PM2. 5 induces aberrant activation of NF-κB in human airway epithelial cells by downregulating miR-331 expression

L Song, D Li, X Li, L Ma, X Bai, Z Wen, X Zhang… - Environmental …, 2017 - Elsevier
Exposure to particulate matter (PM) with an aerodynamic diameter≤ 2.5 μm (PM2. 5)
induces reactive oxygen species (ROS) and pro-inflammatory cytokine production, leading …

Ambient particulate matter induces interleukin-8 expression through an alternative NF-κB (nuclear factor-kappa B) mechanism in human airway epithelial cells

R Silbajoris, AR Osornio-Vargas… - Environmental …, 2011 - ehp.niehs.nih.gov
Background: Exposure to ambient air particulate matter (PM) has been shown to increase
rates of cardiopulmonary morbidity and mortality, but the underlying mechanisms are still not …

Exposure to particulate matter 2.5 (PM2. 5) induced macrophage-dependent inflammation, characterized by increased Th1/Th17 cytokine secretion and cytotoxicity

QY Ma, DY Huang, HJ Zhang, S Wang… - International …, 2017 - Elsevier
Particulate matter PM2. 5 is a class of airborne particles and droplets with sustained high
levels in many developing countries. Epidemiological studies have shown the association …

Effects on IL-1β signaling activation induced by water and organic extracts of fine particulate matter (PM2. 5) in vitro

F Xu, X Qiu, X Hu, Y Shang, M Pardo, Y Fang… - Environmental …, 2018 - Elsevier
Abstract Fine particulate matter (PM 2.5) air pollution poses a major risk to human health
worldwide, and absorbed chemicals play a key role in determining the toxicity of PM 2.5 …