Progressive impairment of CaV1.1 function in the skeletal muscle of mice expressing a mutant type 1 Cu/Zn superoxide dismutase (G93A) linked to amyotrophic …
D Beqollari, CF Romberg, G Dobrowolny, M Martini… - Skeletal muscle, 2016 - Springer
Background Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative
disorder that is typically fatal within 3–5 years of diagnosis. While motoneuron death is the …
disorder that is typically fatal within 3–5 years of diagnosis. While motoneuron death is the …
Voltage-gated calcium channels are abnormal in cultured spinal motoneurons in the G93A-SOD1 transgenic mouse model of ALS
Q Chang, LJ Martin - Neurobiology of disease, 2016 - Elsevier
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by
progressive loss of motoneurons. Hyperexcitability and excitotoxicity have been implicated …
progressive loss of motoneurons. Hyperexcitability and excitotoxicity have been implicated …
Cu/Zn superoxide dismutase typical for familial amyotrophic lateral sclerosis increases the vulnerability of mitochondria and perturbs Ca2+ homeostasis in SOD1G93A …
MK Jaiswal, BU Keller - Molecular pharmacology, 2009 - ASPET
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by
the selective loss of defined motoneuron populations in the brainstem and spinal cord …
the selective loss of defined motoneuron populations in the brainstem and spinal cord …
Hyperactive intracellular calcium signaling associated with localized mitochondrial defects in skeletal muscle of an animal model of amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is a fatal neuromuscular disorder characterized by
degeneration of motor neurons and atrophy of skeletal muscle. Mutations in the superoxide …
degeneration of motor neurons and atrophy of skeletal muscle. Mutations in the superoxide …
Perturbations in intracellular Ca2+ handling in skeletal muscle in the G93A*SOD1 mouse model of amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease
characterized by skeletal muscle atrophy and weakness, ultimately leading to respiratory …
characterized by skeletal muscle atrophy and weakness, ultimately leading to respiratory …
Intact single muscle fibres from SOD1G93A amyotrophic lateral sclerosis mice display preserved specific force, fatigue resistance and training‐like adaptations
Key points How defects in muscle contractile function contribute to weakness in amyotrophic
lateral sclerosis (ALS) were systematically investigated. Weakness in whole muscles from …
lateral sclerosis (ALS) were systematically investigated. Weakness in whole muscles from …
Low Ca2+ buffering in hypoglossal motoneurons of mutant SOD1 (G93A) mice
F von Lewinski, J Fuchs, BK Vanselow, BU Keller - Neuroscience letters, 2008 - Elsevier
Mutations in the Cu/Zn superoxide dismutase (SOD1) gene are associated with amyotrophic
lateral sclerosis (ALS), a fatal neurodegenerative disorder characterized by a selective …
lateral sclerosis (ALS), a fatal neurodegenerative disorder characterized by a selective …
Muscle contractility dysfunction precedes loss of motor unit connectivity in SOD1 (G93A) mice
CG Wier, AE Crum, AB Reynolds, CC Iyer… - Muscle & …, 2019 - Wiley Online Library
Introduction: Electrophysiological measurements are used in longitudinal clinical studies to
provide insight into the progression of amyotrophic lateral sclerosis (ALS) and the …
provide insight into the progression of amyotrophic lateral sclerosis (ALS) and the …
[HTML][HTML] Presymptomatic biochemical changes in hindlimb muscle of G93A human Cu/Zn superoxide dismutase 1 transgenic mouse model of amyotrophic lateral …
KHJ Park, I Vincent - Biochimica et Biophysica Acta (BBA)-Molecular Basis …, 2008 - Elsevier
Amyotrophic lateral sclerosis (ALS) is primarily a motor neuron disorder. Intriguingly, early
muscle denervation preceding motor neuron loss is observed in mouse models of ALS …
muscle denervation preceding motor neuron loss is observed in mouse models of ALS …
Selective mitochondrial Ca2+ uptake deficit in disease endstage vulnerable motoneurons of the SOD1G93A mouse model of amyotrophic lateral sclerosis
A Fuchs, S Kutterer, T Mühling, J Duda… - The Journal of …, 2013 - Wiley Online Library
Key points• So far, increased excitability and calcium handling problems have been
discussed as causes for motoneuron death in amyotrophic lateral sclerosis (ALS) mainly on …
discussed as causes for motoneuron death in amyotrophic lateral sclerosis (ALS) mainly on …