Life expectancy has grown dramatically in modern times. This increase, however, is not
accompanied by the same increase in healthspan. Efforts to extend healthspan through …

Aging is a physiological process mediated by numerous biological and genetic pathways,
which are directly linked to lifespan and are a driving force for all age-related diseases …

Introduction: Scientific achievements in the last few decades, leading to effective therapeutic
interventions, have dramatically improved human life expectancy. Consequently, aging has …

The phenomenon of aging is an intrinsic feature of life. Accordingly, the possibility to
manipulate it has fascinated humans likely since time immemorial. Recent evidence is …

Background Most modern societies undergo rapid population aging. The rise in life
expectancy, nevertheless, is not accompanied, to date, by the same increment of …

The steady rise in life expectancy occurred across all developed countries during the last
century. This demographic trend is, however, not accompanied by the same healthspan …

Human longevity has increased dramatically during the past century. More than 20% of the 9
billion population of the world will exceed the age of 60 in 2050. Since the last three …

For many years, it was believed that the aging process was inevitable and that age‐related
diseases could not be prevented or reversed. The geroscience hypothesis, however, posits …

Aging is one of the world's greatest concerns, requiring urgent, effective, large-scale
interventions to decrease the number of late-life chronic diseases and improve human …

The risk of morbidity and mortality increases exponentially with age. Chronic inflammation,
accumulation of DNA damage, dysfunctional mitochondria, and increased senescent cell …