During malignant transformation, glycosylation is heavily altered compared with healthy
tissue due to differential expression of glycosyltransferases, glycosidases and …

Sialic acids represent a family of sugar molecules derived from neuraminic acid that
frequently terminate glycan chains and contribute to many biological processes. Already five …

Sialic acids, a subset of nine carbon acidic sugars, often exist as the terminal sugars of
glycans on either glycoproteins or glycolipids on the cell surface. Sialic acids play important …

Sialic acids are common monosaccharides that are widely expressed as outer terminal units
on all vertebrate cell surfaces, and play fundamental roles in cell–cell and cell …

Over four decades ago, specific tumor characteristics were ascribed to the increased
expression of sialic acid sugars on the surface of cancer cells, and this led to the definition of …

One of the frontiers in cancer personalized-medicine aims at glycosylation. Cells are
covered with a dense sugar coat of glycolipids, glycoproteins and free glycans. In cancer …

Cell surface glycosylation is dynamic and often changes in response to cellular
differentiation under physiological or pathophysiological conditions. Altered glycosylation on …

Simple Summary All cells are covered in a thick layer of sugar molecules known as glycans.
Changes to this sugar coat are common in cancer, and in particular cancer cells often …

Sialic acids (Sias) are typically found as terminal monosaccharides attached to cell surface
glycoconjugates. They play many important roles in many physiological and pathological …

The term sialic acid is used to describe derivatives of neuraminic acid, where the amino
group of neuraminic acid is substituted by either an acetyl or glycolyl group. The unique …