Cardiometabolic risk loci share downstream cis-and trans-gene regulation across tissues and diseases
Genome-wide association studies (GWAS) have identified hundreds of cardiometabolic
disease (CMD) risk loci. However, they contribute little to genetic variance, and most …
disease (CMD) risk loci. However, they contribute little to genetic variance, and most …
A mechanistic framework for cardiometabolic and coronary artery diseases
Coronary atherosclerosis results from the delicate interplay of genetic and exogenous risk
factors, principally taking place in metabolic organs and the arterial wall. Here we show that …
factors, principally taking place in metabolic organs and the arterial wall. Here we show that …
Large-scale genome-wide association study of coronary artery disease in genetically diverse populations
We report a genome-wide association study (GWAS) of coronary artery disease (CAD)
incorporating nearly a quarter of a million cases, in which existing studies are integrated with …
incorporating nearly a quarter of a million cases, in which existing studies are integrated with …
[HTML][HTML] Adipose tissue gene expression associations reveal hundreds of candidate genes for cardiometabolic traits
Genome-wide association studies (GWASs) have identified thousands of genetic loci
associated with cardiometabolic traits including type 2 diabetes (T2D), lipid levels, body fat …
associated with cardiometabolic traits including type 2 diabetes (T2D), lipid levels, body fat …
Large-scale association analysis identifies new risk loci for coronary artery disease
CARDIoGRAMplusC4D Consortium, P Deloukas… - Nature …, 2013 - nature.com
Coronary artery disease (CAD) is the commonest cause of death. Here, we report an
association analysis in 63,746 CAD cases and 130,681 controls identifying 15 loci reaching …
association analysis in 63,746 CAD cases and 130,681 controls identifying 15 loci reaching …
[HTML][HTML] Integrative functional genomics identifies regulatory mechanisms at coronary artery disease loci
Coronary artery disease (CAD) is the leading cause of mortality and morbidity, driven by
both genetic and environmental risk factors. Meta-analyses of genome-wide association …
both genetic and environmental risk factors. Meta-analyses of genome-wide association …
[PDF][PDF] Intersecting single-cell transcriptomics and genome-wide association studies identifies crucial cell populations and candidate genes for atherosclerosis
L Slenders, LPL Landsmeer, K Cui… - … heart journal open, 2022 - academic.oup.com
Aims Genome-wide association studies (GWASs) have discovered hundreds of common
genetic variants for atherosclerotic disease and cardiovascular risk factors. The translation of …
genetic variants for atherosclerotic disease and cardiovascular risk factors. The translation of …
[HTML][HTML] Integrative genomics reveals novel molecular pathways and gene networks for coronary artery disease
The majority of the heritability of coronary artery disease (CAD) remains unexplained,
despite recent successes of genome-wide association studies (GWAS) in identifying novel …
despite recent successes of genome-wide association studies (GWAS) in identifying novel …
Systems genetics analysis of genome-wide association study reveals novel associations between key biological processes and coronary artery disease
Objective—Genome-wide association studies have identified multiple genetic variants
affecting the risk of coronary artery disease (CAD). However, individually these explain only …
affecting the risk of coronary artery disease (CAD). However, individually these explain only …
Comparative analysis of genome-wide association studies signals for lipids, diabetes, and coronary heart disease: Cardiovascular Biomarker Genetics Collaboration
A Angelakopoulou, T Shah, R Sofat… - European heart …, 2012 - academic.oup.com
Aims To evaluate the associations of emergent genome-wide-association study-derived
coronary heart disease (CHD)-associated single nucleotide polymorphisms (SNPs) with …
coronary heart disease (CHD)-associated single nucleotide polymorphisms (SNPs) with …