Several new derivatives of 5, 5′‐(ethane‐1, 2‐diyl) bis (3‐((5‐bromo‐6‐methyl‐2‐
tertiaryamino pyrimidin‐4‐yl) thio)‐4H‐1, 2, 4‐triazol‐4‐amine)(4a, 4b, 4c, 4d, 4e, 4f) and …

A series of new 3, 5‐bis ((5‐bromo‐6‐methyl‐2‐t‐aminopyrimidin‐4‐yl) thio)‐4H‐1, 2, 4‐
triazol‐4‐amines and their cyclized products 'pyrimidinylthio pyrimidotriazolothiadiazines' …

A group of 2-substituted pyrimido [4, 5-b][1, 4] benzothiazines were designed, synthesized,
and evaluated as potential inhibitors of 15-lipoxygenase (15-LO). Compounds 4d and 4e …

BACKGROUND AND PURPOSE 5‐Lipoxygenase (5‐LO) is the key enzyme in the
biosynthesis of pro‐inflammatory leukotrienes (LTs) representing a potential target for …

Synthesis of new derivatives of pyrimido[5,4-e][1,2,4]triazolo[3,4-b] [1,3,4]thiadiazine and
their enzyme inhibitory activity as Page 1 48 RESEARCH PAPER JOURNAL OF …

A new group of 3-substituted-5H-benzo [5, 6][1, 4] thiazino [3, 2-e][1, 2, 4] triazines was
designed, synthesized and evaluated as inhibitors of 15-lipoxygenase (15-LO), and the …

The strategy and SAR studies that led to the discovery of a novel potent and orally available
5-lipoxygenase (5-LO) inhibitor 3-(4-fluorophenyl)-6-({4-[(1S)-1-hydroxy-1-(trifluoromethyl) …

A series of 2-chloro-quinoline-based imidazopyridines 6a–l and imidazothiazoles 6m–o
bearing a bulky alkylamine side chain were synthesized as soybean 15-LOX inhibitors. The …

PII: 0960-894X(94)00449-P Page 1 Pergamon Bioorganic & Medicinal Chemistry Letters, Vol. 5,
No. 1, pp. 35-38, 1995 Copyright © 1994 Elsevier Science Ltd Printed in Great Britain. All rights …

A convenient synthetic route to 4-[3-(4-heterocyclylphenylthio) phenyl]-3, 4, 5, 6-tetrahydro-
2H-pyran-4-carboxamide analogues as 5-LO inhibitors is described. This methodology …