Histone deacetylase 6 is a multifunctional lysine deacetylase that is recently emerging as a
central facilitator of response to stress and may play an important role in cancer cell …

Tumor cells activate autophagy in response to chemotherapy-induced DNA damage as a
survival program to cope with metabolic stress. Here, we provide in vitro and in vivo …

Ubiquitin‐binding histone deacetylase 6 (HDAC6) is uniquely endowed with tubulin
deacetylase activity and plays an important role in the clearance of misfolded protein by …

This study aimed to investigate the roles of autophagy and the ubiquitin-proteasome system
in the degradation of histone deacetylase 8 (HDAC8) and to clarify the mechanism by which …

Cancer stem-like cells (CSCs), a small population of pluripotent cells residing within
heterogeneous tumor mass, remain highly resistant to various chemotherapies as compared …

Simple Summary Autophagy is an essential process in cell recycling, and its involvement in
cancer has been increasingly recognized in the last few decades. This mechanism acts as a …

Pancreatic cancer is a devastating disease with the worst prognosis among all the major
human malignancies. The propensity to rapidly metastasize contributes significantly to the …

Abstract Histone deacetylase 6 (HDAC6) promotes cell motility and contributes to the
metastasis of cancers. The purpose of this study was to investigate the role of HDAC6 in …

Background Cytosolic deacetylase histone deacetylase 6 (HDAC6) is involved in the
autophagy degradation pathway of malformed proteins, an important survival mechanism in …

Autophagy is a conserved mechanism for controlling the degradation of misfolded proteins
and damaged organelles in eukaryotes and can be induced by nutrient withdrawal …