[HTML][HTML] NTRK gene fusions as novel targets of cancer therapy across multiple tumour types
The tropomyosin receptor kinase (Trk) receptor family comprises 3 transmembrane proteins
referred to as Trk A, B and C (TrkA, TrkB and TrkC) receptors that are encoded by the …
referred to as Trk A, B and C (TrkA, TrkB and TrkC) receptors that are encoded by the …
Targeting TRK family proteins in cancer
YB Khotskaya, VR Holla, AF Farago, KRM Shaw… - Pharmacology & …, 2017 - Elsevier
The tropomyosin receptor kinase (TRK) family includes TRKA, TRKB, and TRKC proteins,
which are encoded by NTRK1, NTRK2 and NTRK3 genes, respectively. Binding of …
which are encoded by NTRK1, NTRK2 and NTRK3 genes, respectively. Binding of …
A review of NTRK fusions in cancer
CA Manea, DC Badiu, IC Ploscaru… - Annals of Medicine …, 2022 - journals.lww.com
The family of the neurotrophic tropomyosin kinase receptors (NTRK or TRK) is a part of the
transmembrane tyrosine kinases responsible for neuronal development. The members of …
transmembrane tyrosine kinases responsible for neuronal development. The members of …
Inhibiting TRK proteins in clinical cancer therapy
AM Lange, HW Lo - Cancers, 2018 - mdpi.com
Gene rearrangements resulting in the aberrant activity of tyrosine kinases have been
identified as drivers of oncogenesis in a variety of cancers. The tropomyosin receptor kinase …
identified as drivers of oncogenesis in a variety of cancers. The tropomyosin receptor kinase …
[HTML][HTML] Tropomyosin receptor kinase (TRK) biology and the role of NTRK gene fusions in cancer
The tropomyosin receptor kinase (TRK) family of receptor tyrosine kinases are encoded by
NTRK genes and have a role in the development and normal functioning of the nervous …
NTRK genes and have a role in the development and normal functioning of the nervous …
[HTML][HTML] NTRK insights: best practices for pathologists
JF Hechtman - Modern Pathology, 2022 - Elsevier
Since the discovery of an oncogenic tropomyosin-receptor kinase (TRK) fusion protein in the
early 1980s, our understanding of neurotrophic tropomyosin-receptor kinase (NTRK) …
early 1980s, our understanding of neurotrophic tropomyosin-receptor kinase (NTRK) …
Testing algorithm for identification of patients with TRK fusion cancer
F Penault-Llorca, ER Rudzinski… - Journal of clinical …, 2019 - jcp.bmj.com
The neurotrophic tyrosine receptor kinase (NTRK) gene family encodes three tropomyosin
receptor kinases (TRKA, TRKB, TRKC) that contribute to central and peripheral nervous …
receptor kinases (TRKA, TRKB, TRKC) that contribute to central and peripheral nervous …
[HTML][HTML] Development of small-molecule tropomyosin receptor kinase (TRK) inhibitors for NTRK fusion cancers
T Jiang, G Wang, Y Liu, L Feng, M Wang, J Liu… - … Pharmaceutica Sinica B, 2021 - Elsevier
Tropomyosin receptor kinase A, B and C (TRKA, TRKB and TRKC), which are well-known
members of the cell surface receptor tyrosine kinase (RTK) family, are encoded by the …
members of the cell surface receptor tyrosine kinase (RTK) family, are encoded by the …
Emerging Targeted Therapy for Tumors with NTRK Fusion Proteins
ES Kheder, DS Hong - Clinical Cancer Research, 2018 - AACR
The oncogenesis-promoting role of chromosomal rearrangements for several hematologic
and solid malignancies is well recognized. However, identifying targetable, actionable, and …
and solid malignancies is well recognized. However, identifying targetable, actionable, and …
Tropomyosin receptor kinase inhibitors for the treatment of TRK fusion cancer
TW Laetsch, DS Hong - Clinical Cancer Research, 2021 - AACR
Chromosomal rearrangements of NTRK1–3 resulting in gene fusions (NTRK gene fusions)
have been clinically validated as oncogenic drivers in a wide range of human cancers …
have been clinically validated as oncogenic drivers in a wide range of human cancers …